Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/160034
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dc.contributor.authorTeo, Ting Weien_US
dc.contributor.authorShen, Xinhuien_US
dc.contributor.authorTan, Pei Yenen_US
dc.contributor.authorMarcosen_US
dc.date.accessioned2022-07-12T08:53:37Z-
dc.date.available2022-07-12T08:53:37Z-
dc.date.issued2022-
dc.identifier.citationTeo, T. W., Shen, X., Tan, P. Y. & Marcos (2022). A microfluidic approach to investigate the effects of bacteria deposition in porous media containing randomly packed microbeads via real-time pressure measurement. Microfluidics and Nanofluidics, 26(8), 58-. https://dx.doi.org/10.1007/s10404-022-02561-zen_US
dc.identifier.issn1613-4982en_US
dc.identifier.urihttps://hdl.handle.net/10356/160034-
dc.description.abstractWe present a real-time microfluidic permeability characterization device for quantifying effects of bacterial deposition on permeability of porous media. Here, we demonstrate a microfluidic approach that allows the effect of bacterial deposition on permeability alteration to be quantified via the measurement of pressure difference, coupled with direct visualization of bacterial distribution. Our experiments reveal three main findings. First, we observe the average percent of cell trapped to be 44.8 ± 9.7%, independent of the average bacterial density at three levels of concentration between 2.05 × 10^7 and 2.85 × 10^8 cells/ml. Second, the deposited bacterial cell count appears to follow an exponential reduction in permeability, where the reduction of permeability approaches a pseudo-steady state when a critical number of bacterial cell deposited is achieved. Last, the experiment discerned that bacterial cells tend to preferentially get deposited in regions with larger voids within the porous medium. A theoretical model is developed to determine the relationship between the spatial distribution of voids in the porous medium and the resultant bacterial cell density distribution. The approach described here shows good potential for better understanding the relationship between the spatial distribution of voids and deposited bacteria. More work can be done to further investigate these interactions, such as strategically designed voids to enhance the deposition of bacterial cells, or quantification of inflow bacterial density required to achieve a desired level of pseudo-steady state permeability reduction under various environmental conditions.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relationMOE2018-T2-2-052en_US
dc.relationRT04/19en_US
dc.relation.ispartofMicrofluidics and Nanofluidicsen_US
dc.rights© 2021 The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. This paper was published in Microfluidics and Nanofluidics and is made available with permission of The Author(s).en_US
dc.subjectEngineering::Mechanical engineering::Fluid mechanicsen_US
dc.subjectScience::Biological sciences::Microbiology::Bacteriaen_US
dc.titleA microfluidic approach to investigate the effects of bacteria deposition in porous media containing randomly packed microbeads via real-time pressure measurementen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.identifier.doi10.1007/s10404-022-02561-z-
dc.description.versionSubmitted/Accepted versionen_US
dc.identifier.issue8en_US
dc.identifier.volume26en_US
dc.identifier.spage58en_US
dc.subject.keywordsBacterial Depositionen_US
dc.subject.keywordsBacterial Distributionen_US
dc.subject.keywordsPressure Differenceen_US
dc.subject.keywordsReduction of Permeabilityen_US
dc.subject.keywordsVoid Distributionen_US
dc.description.acknowledgementThis research is supported by the Ministry of Education, Singapore, under its Academic Research Funds Tier 2 MOE2018-T2-2-052 and Academic Research Funds Tier 1 RT04/19en_US
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