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Title: Enantiospecific molecular fingerprinting using potential-modulated surface-enhanced Raman scattering to achieve label-free chiral differentiation
Authors: Leong, Shi Xuan
Koh, Charlynn Sher Lin
Sim, Howard Yi Fan
Lee, Yih Hong
Han, Xuemei
Phan-Quang, Gia Chuong
Ling, Xing Yi
Keywords: Science::Chemistry
Issue Date: 2021
Source: Leong, S. X., Koh, C. S. L., Sim, H. Y. F., Lee, Y. H., Han, X., Phan-Quang, G. C. & Ling, X. Y. (2021). Enantiospecific molecular fingerprinting using potential-modulated surface-enhanced Raman scattering to achieve label-free chiral differentiation. ACS Nano, 15(1), 1817-1825.
Project: RG11/18
Journal: ACS Nano
Abstract: Chiral differentiation is critical in diverse fields ranging from pharmaceutics to chiral synthesis. While surface-enhanced Raman scattering (SERS) offers molecule-specific vibrational information with high detection sensitivity, current strategies rely on indirect detection using additional selectors and cannot exploit SERS' key advantages for univocal and generic chiral differentiation. Here, we achieve direct, label-free SERS sensing of biologically important enantiomers by synergizing asymmetric nanoporous gold (NPG) nanoparticles with electrochemical-SERS to generate enantiospecific molecular fingerprints. Experimental and in silico studies reveal that chiral recognition is two pronged. First, the numerous surface atomic defects in NPG provide the necessary localized asymmetric environment to induce enantiospecific molecular adsorptions and interaction affinities. Concurrently, the applied potential drives and orients the enantiomers close to the NPG surface for maximal analyte-surface interactions. Notably, our strategy is versatile and can be readily extended to detect various enantiomers. Furthermore, we can achieve multiplex quantification of enantiomeric ratios with excellent predictive performance. Our combinatorial approach thus offers an important paradigm shift from current approaches to achieve label-free chiral SERS sensing of various enantiomers.
ISSN: 1936-0851
DOI: 10.1021/acsnano.0c09670
Schools: School of Physical and Mathematical Sciences 
Rights: © 2021 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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