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Title: Bioinspired short peptide hydrogel for versatile encapsulation and controlled release of growth factor therapeutics
Authors: Hiew, Shu Hui 
Wang, Jun Kit
Koh, Kenrick
Yang, Haibo
Bacha, Abbas
Lin, Junquan
Yip, Yun Sheng
Vos, Marcus Ivan Gerard
Chen, Liyan
Sobota, Radoslaw M.
Tan, Nguan Soon
Tay, Chor Yong
Miserez, Ali
Keywords: Engineering::Materials
Issue Date: 2021
Source: Hiew, S. H., Wang, J. K., Koh, K., Yang, H., Bacha, A., Lin, J., Yip, Y. S., Vos, M. I. G., Chen, L., Sobota, R. M., Tan, N. S., Tay, C. Y. & Miserez, A. (2021). Bioinspired short peptide hydrogel for versatile encapsulation and controlled release of growth factor therapeutics. Acta Biomaterialia, 136, 111-123.
Project: 2018T2-1-043
Journal: Acta Biomaterialia
Abstract: A short bioinspired octapeptide, GV8, can self-assemble under mild conditions into biodegradable supramolecular physical hydrogels with high storage modulus and good biocompatibility. GV8 hydrogels can encapsulate both single or multiple macromolecular protein-based therapeutics in a simple one-pot formulation manner, making it a promising candidate to address challenges faced by existing synthetic polymer or peptide hydrogels with complex gelation and drug-encapsulation processes. Alongside its versatility, the hydrogel exhibits concentration-dependent storage modulus and controlled drug-release action. We demonstrate that GV8 hydrogels loaded with adipose-derived mesenchymal stem cells (ADMSC) secretome remain mechanically robust, and exhibit promising potential for wound healing applications by preserving secretome activity while maintaining a constant supply of ADMSC secretome to promote epithelial cell migration. Overall, our work highlights the potential of GV8 peptide hydrogel as a versatile and safe carrier for encapsulation and delivery of macromolecular therapeutics.
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2021.09.023
Schools: School of Materials Science and Engineering 
School of Biological Sciences 
Interdisciplinary Graduate School (IGS) 
Lee Kong Chian School of Medicine (LKCMedicine) 
Research Centres: Center for Sustainable Materials
Environmental Chemistry and Materials Centre
NTU Institute for Health Technologies 
Nanyang Environment and Water Research Institute 
Rights: © 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:IGS Journal Articles
LKCMedicine Journal Articles
MSE Journal Articles
NEWRI Journal Articles
SBS Journal Articles

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