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Title: Metabolic labeling mediated targeting and thermal killing of Gram-positive bacteria by self-reporting Janus magnetic nanoparticles
Authors: Hou, Shuai
Mahadevegowda, Surendra Hittanahalli
Lu, Derong
Zhang, Kaixi
Chan-Park, Mary B.
Duan, Hongwei
Keywords: Engineering::Materials
Issue Date: 2021
Source: Hou, S., Mahadevegowda, S. H., Lu, D., Zhang, K., Chan-Park, M. B. & Duan, H. (2021). Metabolic labeling mediated targeting and thermal killing of Gram-positive bacteria by self-reporting Janus magnetic nanoparticles. Small, 17(2), 2006357-.
Project: MOE2013-T3-1-002 
Journal: Small 
Abstract: Nanoparticles have been widely used in detection and killing of bacteria; however, targeting bacteria is still challenging. Delicate design of nanoparticles is required for simultaneous targeting, detection, and therapeutic functions. Here the use of Au/MnFe2 O4 (Au/MFO) Janus nanoparticles to target Gram-positive bacteria via metabolic labeling is reported and realize integrated self-reporting and thermal killing of bacteria. In these nanoparticles, the Au component is functionalized with tetrazine to target trans-cyclooctene group anchored on bacterial cell wall by metabolic incorporation of d-amino acids, and the MFO part exhibits peroxidase activity, enabling self-reporting of bacteria before treatment. The spatial separation of targeting and reporting functions avoids the deterioration of catalytic activity after surface modification. Also important is that MFO facilitates magnetic separation and magnetic heating, leading to easy enrichment and magnetic thermal therapy of labeled bacteria. This method demonstrates that metabolic labeling with d-amino acids is a promising strategy to specifically target and kill Gram-positive bacteria.
ISSN: 1613-6810
DOI: 10.1002/smll.202006357
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2020 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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