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dc.contributor.authorLiu, Yanen_US
dc.contributor.authorXie, Jieen_US
dc.contributor.authorWang, Menggeen_US
dc.contributor.authorLiu, Changhuien_US
dc.contributor.authorZhu, Jingrongen_US
dc.contributor.authorZou, Xingen_US
dc.contributor.authorLi, Wenshanen_US
dc.contributor.authorWang, Linen_US
dc.contributor.authorLeng, Cuoen_US
dc.contributor.authorXu, Quyien_US
dc.contributor.authorYeh, Hui-Yuanen_US
dc.contributor.authorWang, Chuan-Chaoen_US
dc.contributor.authorWen, Xiaohongen_US
dc.contributor.authorLiu, Chaoen_US
dc.contributor.authorHe, Guanglinen_US
dc.identifier.citationLiu, Y., Xie, J., Wang, M., Liu, C., Zhu, J., Zou, X., Li, W., Wang, L., Leng, C., Xu, Q., Yeh, H., Wang, C., Wen, X., Liu, C. & He, G. (2022). Genomic insights into the population history and biological adaptation of southwestern Chinese Hmong–Mien people. Frontiers in Genetics, 12, 815160-.
dc.description.abstractHmong-Mien (HM) -speaking populations, widely distributed in South China, the north of Thailand, Laos, and Vietnam, have experienced different settlement environments, dietary habits, and pathogenic exposure. However, their specific biological adaptation remained largely uncharacterized, which is important in the population evolutionary genetics and Trans-Omics for regional Precision Medicine. Besides, the origin and genetic diversity of HM people and their phylogenetic relationship with surrounding modern and ancient populations are also unknown. Here, we reported genome-wide SNPs in 52 representative Miao people and combined them with 144 HM people from 13 geographically representative populations to characterize the full genetic admixture and adaptive landscape of HM speakers. We found that obvious genetic substructures existed in geographically different HM populations; one localized in the HM clines, and others possessed affinity with Han Chinese. We also identified one new ancestral lineage specifically existed in HM people, which spatially distributed from Sichuan and Guizhou in the north to Thailand in the south. The sharing patterns of the newly identified homogenous ancestry component combined the estimated admixture times via the decay of linkage disequilibrium and haplotype sharing in GLOBETROTTER suggested that the modern HM-speaking populations originated from Southwest China and migrated southward in the historic period, which is consistent with the reconstructed phenomena of linguistic and archeological documents. Additionally, we identified specific adaptive signatures associated with several important human nervous system biological functions. Our pilot work emphasized the importance of anthropologically informed sampling and deeply genetic structure reconstruction via whole-genome sequencing in the next step in the deep Chinese Population Genomic Diversity Project (CPGDP), especially in the regions with rich ethnolinguistic diversity.en_US
dc.relation.ispartofFrontiers in Geneticsen_US
dc.rights© 2022 Liu, Xie, Wang, Liu, Zhu, Zou, Li, Wang, Leng, Xu, Yeh, Wang, Wen, Liu and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.titleGenomic insights into the population history and biological adaptation of southwestern Chinese Hmong–Mien peopleen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Humanitiesen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsChinese Population Genetic Diversity Projecten_US
dc.subject.keywordsBiological Adaptationen_US
dc.description.acknowledgementThis work was funded by the Project funded by the China Postdoctoral Science Foundation (2021M691879), the Opening project of Medical Imaging Key Laboratory of Sichuan Province (MIKLSP202104), the Science and Technology Program of Guangzhou, China (2019030016), the “Double First Class University Plan” key construction project of Xiamen University (the origin and evolution of East Asian populations and the spread of Chinese civilization), the National Natural Science Foundation of China (NSFC31801040), the Nanqiang Outstanding Young Talents Program of Xiamen University (X2123302), the Major Project of National Social Science Foundation of China (20&ZD248), and the European Research Council (ERC) grant to Dan Xu (ERC-2019-ADG-883700-TRAM).en_US
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