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Title: Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion
Authors: Monzo, Pascale
Crestani, Michele
Chong, Yuk Kien
Ghisleni, Andrea
Hennig, Katharina
Li, Qingsen
Kakogiannos, Nikolaos
Giannotta, Monica
Richichi, Cristina
Dini, Tania
Dejana, Elisabetta
Maiuri, Paolo
Balland, Martial
Sheetz, Michael P.
Pelicci, Giuliana
Ang, Beng Ti
Tang, Carol
Gauthier, Nils C.
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Monzo, P., Crestani, M., Chong, Y. K., Ghisleni, A., Hennig, K., Li, Q., Kakogiannos, N., Giannotta, M., Richichi, C., Dini, T., Dejana, E., Maiuri, P., Balland, M., Sheetz, M. P., Pelicci, G., Ang, B. T., Tang, C. & Gauthier, N. C. (2021). Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion. Developmental Cell, 56(20), 2841-2855.e8.
Project: WBSR714-016-007-271
Journal: Developmental Cell
Abstract: Glioblastoma are heterogeneous tumors composed of highly invasive and highly proliferative clones. Heterogeneity in invasiveness could emerge from discrete biophysical properties linked to specific molecular expression. We identified clones of patient-derived glioma propagating cells that were either highly proliferative or highly invasive and compared their cellular architecture, migratory, and biophysical properties. We discovered that invasiveness was linked to cellular fitness. The most invasive cells were stiffer, developed higher mechanical forces on the substrate, and moved stochastically. The mechano-chemical-induced expression of the formin FMN1 conferred invasive strength that was confirmed in patient samples. Moreover, FMN1 expression was also linked to motility in other cancer and normal cell lines, and its ectopic expression increased fitness parameters. Mechanistically, FMN1 acts from the microtubule lattice and promotes a robust mechanical cohesion, leading to highly invasive motility.
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2021.09.007
Schools: School of Biological Sciences 
Rights: © 2021 Elsevier Inc. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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