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https://hdl.handle.net/10356/160330| Title: | Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy | Authors: | Wu, Kan Xing Yeo, Natalie Jia Ying Ng, Chun Yi Chioh, Florence Wen Jing Fan, Qiao Tian, Xianfeng Yang, Binxia Narayanan, Gunaseelan Tay, Hui Min Hou, Han Wei Dunn, Norris Ray Su, Xinyi Cheung, Gemmy Chui Ming Cheung, Christine |
Keywords: | Science::Medicine | Issue Date: | 2022 | Source: | Wu, K. X., Yeo, N. J. Y., Ng, C. Y., Chioh, F. W. J., Fan, Q., Tian, X., Yang, B., Narayanan, G., Tay, H. M., Hou, H. W., Dunn, N. R., Su, X., Cheung, G. C. M. & Cheung, C. (2022). Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy. BMC Biology, 20(1), 47-. https://dx.doi.org/10.1186/s12915-022-01244-z | Project: | MOE2018-T2-1-042 SPF2014/002 CRP21-2018-00103 |
Journal: | BMC Biology | Abstract: | Polypoidal choroidal vasculopathy (PCV), a subtype of age-related macular degeneration (AMD), is a global leading cause of vision loss in older populations. Distinct from typical AMD, PCV is characterized by polyp-like dilatation of blood vessels and turbulent blood flow in the choroid of the eye. Gold standard anti-vascular endothelial growth factor (anti-VEGF) therapy often fails to regress polypoidal lesions in patients. Current animal models have also been hampered by their inability to recapitulate such vascular lesions. These underscore the need to identify VEGF-independent pathways in PCV pathogenesis. | URI: | https://hdl.handle.net/10356/160330 | ISSN: | 1741-7007 | DOI: | 10.1186/s12915-022-01244-z | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) School of Biological Sciences School of Mechanical and Aerospace Engineering |
Organisations: | Institute of Medical Biology, A*STAR Institute of Molecular and Cell Biology, A*STAR |
Rights: | © 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | LKCMedicine Journal Articles MAE Journal Articles SBS Journal Articles |
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| Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy.pdf | 5.44 MB | Adobe PDF |  View/Open |
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