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dc.contributor.authorWu, Kan Xingen_US
dc.contributor.authorYeo, Natalie Jia Yingen_US
dc.contributor.authorNg, Chun Yien_US
dc.contributor.authorChioh, Florence Wen Jingen_US
dc.contributor.authorFan, Qiaoen_US
dc.contributor.authorTian, Xianfengen_US
dc.contributor.authorYang, Binxiaen_US
dc.contributor.authorNarayanan, Gunaseelanen_US
dc.contributor.authorTay, Hui Minen_US
dc.contributor.authorHou, Han Weien_US
dc.contributor.authorDunn, Norris Rayen_US
dc.contributor.authorSu, Xinyien_US
dc.contributor.authorCheung, Gemmy Chui Mingen_US
dc.contributor.authorCheung, Christineen_US
dc.identifier.citationWu, K. X., Yeo, N. J. Y., Ng, C. Y., Chioh, F. W. J., Fan, Q., Tian, X., Yang, B., Narayanan, G., Tay, H. M., Hou, H. W., Dunn, N. R., Su, X., Cheung, G. C. M. & Cheung, C. (2022). Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy. BMC Biology, 20(1), 47-.
dc.description.abstractPolypoidal choroidal vasculopathy (PCV), a subtype of age-related macular degeneration (AMD), is a global leading cause of vision loss in older populations. Distinct from typical AMD, PCV is characterized by polyp-like dilatation of blood vessels and turbulent blood flow in the choroid of the eye. Gold standard anti-vascular endothelial growth factor (anti-VEGF) therapy often fails to regress polypoidal lesions in patients. Current animal models have also been hampered by their inability to recapitulate such vascular lesions. These underscore the need to identify VEGF-independent pathways in PCV pathogenesis.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.relation.ispartofBMC Biologyen_US
dc.rights© 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver (http://creativeco applies to the data made available in this article, unless otherwise stated in a credit line to the data.en_US
dc.titleHyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathyen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.contributor.organizationInstitute of Medical Biology, A*STARen_US
dc.contributor.organizationInstitute of Molecular and Cell Biology, A*STARen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsEndothelial Dysfunctionen_US
dc.description.acknowledgementThe team from Nanyang Technological University Singapore was funded by the Nanyang Assistant Professorship and Academic Research Fund Tier 2 grant (MOE2018-T2-1-042) from the Ministry of Education, Singapore. N.J.Y.Y is supported by the Nanyang President’s Graduate Scholarship. C.C. and C.M.G.C. were funded by the SERI-IMCB Program in Retinal Angiogenic Diseases (SIPRAD) grant (SPF2014/002) from Agency for Science, Technology and Research, Singapore. X.S. is funded by a grant (CRP21-2018-00103) from the National Research Foundation (Singapore).en_US
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