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Title: Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy
Authors: Wu, Kan Xing
Yeo, Natalie Jia Ying
Ng, Chun Yi
Chioh, Florence Wen Jing
Fan, Qiao
Tian, Xianfeng
Yang, Binxia
Narayanan, Gunaseelan
Tay, Hui Min
Hou, Han Wei
Dunn, Norris Ray
Su, Xinyi
Cheung, Gemmy Chui Ming
Cheung, Christine
Keywords: Science::Medicine
Issue Date: 2022
Source: Wu, K. X., Yeo, N. J. Y., Ng, C. Y., Chioh, F. W. J., Fan, Q., Tian, X., Yang, B., Narayanan, G., Tay, H. M., Hou, H. W., Dunn, N. R., Su, X., Cheung, G. C. M. & Cheung, C. (2022). Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy. BMC Biology, 20(1), 47-.
Project: MOE2018-T2-1-042 
Journal: BMC Biology 
Abstract: Polypoidal choroidal vasculopathy (PCV), a subtype of age-related macular degeneration (AMD), is a global leading cause of vision loss in older populations. Distinct from typical AMD, PCV is characterized by polyp-like dilatation of blood vessels and turbulent blood flow in the choroid of the eye. Gold standard anti-vascular endothelial growth factor (anti-VEGF) therapy often fails to regress polypoidal lesions in patients. Current animal models have also been hampered by their inability to recapitulate such vascular lesions. These underscore the need to identify VEGF-independent pathways in PCV pathogenesis.
ISSN: 1741-7007
DOI: 10.1186/s12915-022-01244-z
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
School of Biological Sciences 
School of Mechanical and Aerospace Engineering 
Organisations: Institute of Medical Biology, A*STAR
Institute of Molecular and Cell Biology, A*STAR
Rights: © 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver (http://creativeco applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles
MAE Journal Articles
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