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Title: Macrolactam synthesis via ring-closing alkene-alkene cross-coupling reactions
Authors: Maraswami, Manikantha
Goh, Jeffrey
Loh, Teck-Peng
Keywords: Science::Chemistry
Issue Date: 2020
Source: Maraswami, M., Goh, J. & Loh, T. (2020). Macrolactam synthesis via ring-closing alkene-alkene cross-coupling reactions. Organic Letters, 22(24), 9724-9728.
Project: RG12/18-S
Journal: Organic Letters
Abstract: Reported herein is a practical method for macrolactam synthesis via a Rh(III)-catalyzed ring closing alkene-alkene cross-coupling reaction. The reaction proceeded via a Rh-catalyzed alkenyl sp2 C-H activation process, which allows access to macrocyclic molecules of different ring sizes. Macrolactams containing a conjugated diene framework could be easily prepared in high chemoselectivities and Z,E stereoselectivities.
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.0c03801
Schools: School of Physical and Mathematical Sciences 
Rights: © 2020 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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