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Title: Large-scale fabrication of 3D scaffold-based patterns of microparticles and breast cancer cells using reusable acoustofluidic device
Authors: Nguyen, Tan Dai
Tran, Van Thai
Pudasaini, Sanam
Gautam, Archana
Lee, Jia Min
Fu, Yong Qing
Du, Hejun
Keywords: Engineering::Mechanical engineering
Issue Date: 2021
Source: Nguyen, T. D., Tran, V. T., Pudasaini, S., Gautam, A., Lee, J. M., Fu, Y. Q. & Du, H. (2021). Large-scale fabrication of 3D scaffold-based patterns of microparticles and breast cancer cells using reusable acoustofluidic device. Advanced Engineering Materials, 23(6), 2001377-.
Project: RG 96/18
Journal: Advanced Engineering Materials
Abstract: Spatial distribution of biological cells plays a key role in tissue engineering for reconstituting the cellular microenvironment, and recently, acoustofluidics are explored as a viable tool for controlling structures in tissue fabrication because of its good biocompatibility, low-power consumption, automation capability, nature of non-invasive, and non-contact. Herein, a reusable acoustofluidic device is developed using surface acoustic waves for manipulating microparticles/cells to form a 3D matrix pattern inside a scaffold-based hydrogel contained in a millimetric chamber. The 3D patterned and polymerized hydrogel construct can be easily and safely removed from the chamber using a proposed lifting technique, which prevent any physical damages or contaminations and promote the reusability of the chamber. The generated 3D patterns of microparticles and cells are numerically studied using a finite-element method, which is well validated by the experimental results. The proposed acoustofluidic device is a useful tool for in vitro engineering 3D scaffold-based artificial tissues for drug and toxicity testing and building organs-on-chip applications.
ISSN: 1438-1656
DOI: 10.1002/adem.202001377
Schools: School of Mechanical and Aerospace Engineering 
Rights: © 2021 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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