Please use this identifier to cite or link to this item:
Title: Evaluation of different OCT systems in quantitative imaging of human Schlemm's canal
Authors: Wu, Xuan
Tan, Bingyao
Gan, Jinyuan
Lam, Adeline R.
Chen, Yibing
Liu, Xinyu
Chua, Jacqueline
Wong, Damon Wing Kee
Ang, Marcus
Schmetterer, Leopold
Yao, Xinwen
Keywords: Engineering::Chemical engineering
Issue Date: 2022
Source: Wu, X., Tan, B., Gan, J., Lam, A. R., Chen, Y., Liu, X., Chua, J., Wong, D. W. K., Ang, M., Schmetterer, L. & Yao, X. (2022). Evaluation of different OCT systems in quantitative imaging of human Schlemm's canal. Scientific Reports, 12(1), 1400-.
Project: CG/C010A/2017_SERI 
Journal: Scientific Reports 
Abstract: We examined the performance of human Schlemm's canal (SC) imaging using different OCT devices: CIRRUS 5000 (840 nm, spectral-domain (SD)-OCT), PLEX Elite 9000 (1060 nm, swept-source (SS)-OCT) and CASIA SS-1000 (1310 nm, SS-OCT), and analyzed potential impact factors on visualization and the quantitative assessment of SC morphology in a pilot study. Ten healthy subjects were imaged using three OCT devices by a single experienced operator on the same day. Each eye underwent two cubic scans by each device, one on nasal and the other on temporal quadrant. The B-scan showing the largest SC was manually selected for processing. Four quantitative metrics, including one morphological metric as cross-sectional area (CSA), and three performance metrics as contrast, continuity, and coverage, were derived from the datasets. Repeated-measures ANOVA was used to investigate the difference between these parameters from the three devices (P < 0.05). We found the CSA measured from CIRRUS was significantly larger than PLEX, followed by CASIA. The contrast was highest in CIRRUS, followed by PLEX and CASIA. The coverage was also higher in CIRRUS as compared to PLEX and CASIA. No significant difference was seen in the continuity from the three devices. In summary, we showed the measurements from the three devices were not interchangeable.
ISSN: 2045-2322
DOI: 10.1038/s41598-022-05410-9
Schools: School of Chemical and Biomedical Engineering 
Organisations: Duke-NUS Medical School 
Singapore National Eye Centre 
Research Centres: SERI-NTU Advanced Ocular Engineering (STANCE)
Rights: © 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

Files in This Item:
File Description SizeFormat 
Evaluation of different OCT systems in quantitative imaging of human Schlemm's canal.pdf1.5 MBAdobe PDFThumbnail

Citations 50

Updated on Jun 12, 2024

Web of ScienceTM
Citations 50

Updated on Oct 31, 2023

Page view(s)

Updated on Jun 15, 2024

Download(s) 50

Updated on Jun 15, 2024

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.