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Title: Internal membrane fouling by proteins during microfiltration
Authors: Lay, Huang Teik
Yeow, Rique Jie En
Ma, Yunqiao
Zydney, Andrew L.
Wang, Rong
Chew, Jia Wei
Keywords: Engineering::Chemical engineering
Issue Date: 2021
Source: Lay, H. T., Yeow, R. J. E., Ma, Y., Zydney, A. L., Wang, R. & Chew, J. W. (2021). Internal membrane fouling by proteins during microfiltration. Journal of Membrane Science, 637, 119589-.
Project: A20B3a0070
2019-T1-002-065; RG100/19
Journal: Journal of Membrane Science
Abstract: The current study aimed to understand both external and internal membrane fouling by three proteins with different net charges, namely, negatively charged pepsin and bovine serum albumin (BSA), as well as positively charged lysozyme. Polycarbonate track-etched (PCTE) membranes were used. Per electrostatic attraction, the flux decline was the worst for lysozyme, which is attributed by the fouling model to the greatest pore blockage (α) and pore constriction (β), and by field-emission scanning electron microscope (FESEM) and optical coherence tomography (OCT) to the most extensive external fouling. Between pepsin and BSA, BSA gave worse flux decline despite its more negative net charge. The fouling model indicates that BSA gave greater pore blockage (α) and denser internal cake (Rc/Rm), while the quartz crystal microbalance with dissipation (QCM-D) indicates a rigid cake structure. Notably, despite monotonic flux decline with filtration, the OCT fouling voxel trends show significant fluctuations, which has not been reported before and thus signify the unique behavior of protein foulants in straight-through pores. Specifically, the trends below and above the −4.5 μm layer (i.e., 4.5 μm below the feed-membrane interface) are perfectly opposite, indicating the non-uniform protein deposits slipping downwards in the membrane pores as filtration progressed. The dynamic movements of the protein cakes unveiled here warrant more understanding in future studies.
ISSN: 0376-7388
DOI: 10.1016/j.memsci.2021.119589
Schools: School of Chemical and Biomedical Engineering 
Interdisciplinary Graduate School (IGS) 
School of Civil and Environmental Engineering 
Research Centres: Singapore Membrane Technology Centre 
Nanyang Environment and Water Research Institute 
Rights: © 2021 Elsevier B.V. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:CEE Journal Articles
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