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Title: A neural circuit for excessive feeding driven by environmental context in mice
Authors: Mohammad, Hasan
Senol, Esra
Graf, Martin
Lee, Chun-Yao
Li, Qin
Liu, Qing
Yeo, Xin Yi
Wang, Menghan
Laskaratos, Achilleas
Xu, Fuqiang
Luo, Sarah Xinwei
Jung, Sangyong
Augustine, George James
Fu, Yu
Keywords: Science::Medicine
Issue Date: 2021
Source: Mohammad, H., Senol, E., Graf, M., Lee, C., Li, Q., Liu, Q., Yeo, X. Y., Wang, M., Laskaratos, A., Xu, F., Luo, S. X., Jung, S., Augustine, G. J. & Fu, Y. (2021). A neural circuit for excessive feeding driven by environmental context in mice. Nature Neuroscience, 24(8), 1132-1141.
Project: 1530700142
Journal: Nature Neuroscience
Abstract: Despite notable genetic influences, obesity mainly results from the overconsumption of food, which arises from the interplay of physiological, cognitive and environmental factors. In patients with obesity, eating is determined more by external cues than by internal physiological needs. However, how environmental context drives non-homeostatic feeding is elusive. Here, we identify a population of somatostatin (TNSST) neurons in the mouse hypothalamic tuberal nucleus that are preferentially activated by palatable food. Activation of TNSST neurons enabled a context to drive non-homeostatic feeding in sated mice and required inputs from the subiculum. Pairing a context with palatable food greatly potentiated synaptic transmission between the subiculum and TNSST neurons and drove non-homeostatic feeding that could be selectively suppressed by inhibiting TNSST neurons or the subiculum but not other major orexigenic neurons. These results reveal how palatable food, through a specific hypothalamic circuit, empowers environmental context to drive non-homeostatic feeding.
ISSN: 1097-6256
DOI: 10.1038/s41593-021-00875-9
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2021 The Author(s), under exclusive licence to Springer Nature America, Inc. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

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