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Title: Genomic basis of striking fin shapes and colors in the fighting fish
Authors: Wang, Le
Sun, Fei
Wan, Zi Yi
Ye, Baoqing
Wen, Yanfei
Liu, Huiming
Yang, Zituo
Pang, Hongyan
Meng, Zining
Fan, Bin
Alfiko, Yuzer
Shen, Yubang
Bai, Bin
Lee, May Shu Qing
Piferrer, Francesc
Schartl, Manfred
Meyer, Axel
Yue, Gen Hua
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Wang, L., Sun, F., Wan, Z. Y., Ye, B., Wen, Y., Liu, H., Yang, Z., Pang, H., Meng, Z., Fan, B., Alfiko, Y., Shen, Y., Bai, B., Lee, M. S. Q., Piferrer, F., Schartl, M., Meyer, A. & Yue, G. H. (2021). Genomic basis of striking fin shapes and colors in the fighting fish. Molecular Biology and Evolution, 38(8), 3383-3396.
Journal: Molecular Biology and Evolution
Abstract: Resolving the genomic basis underlying phenotypic variations is a question of great importance in evolutionary biology. However, understanding how genotypes determine the phenotypes is still challenging. Centuries of artificial selective breeding for beauty and aggression resulted in a plethora of colors, long-fin varieties, and hyper-aggressive behavior in the air-breathing Siamese fighting fish (Betta splendens), supplying an excellent system for studying the genomic basis of phenotypic variations. Combining whole-genome sequencing, quantitative trait loci mapping, genome-wide association studies, and genome editing, we investigated the genomic basis of huge morphological variation in fins and striking differences in coloration in the fighting fish. Results revealed that the double tail, elephant ear, albino, and fin spot mutants each were determined by single major-effect loci. The elephant ear phenotype was likely related to differential expression of a potassium ion channel gene, kcnh8. The albinotic phenotype was likely linked to a cis-regulatory element acting on the mitfa gene and the double-tail mutant was suggested to be caused by a deletion in a zic1/zic4 coenhancer. Our data highlight that major loci and cis-regulatory elements play important roles in bringing about phenotypic innovations and establish Bettas as new powerful model to study the genomic basis of evolved changes.
ISSN: 0737-4038
DOI: 10.1093/molbev/msab110
Schools: School of Biological Sciences 
Rights: © 2021 The Author(s). Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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