Please use this identifier to cite or link to this item:
Title: Studying kidney diseases using organoid models
Authors: Liu, Meng
Cardilla, Angelysia
Ngeow, Joanne
Gong, Ximing
Xia, Yun
Keywords: Science::Medicine
Issue Date: 2022
Source: Liu, M., Cardilla, A., Ngeow, J., Gong, X. & Xia, Y. (2022). Studying kidney diseases using organoid models. Frontiers In Cell And Developmental Biology, 10, 845401-.
Project: MOE2019-T2-1-072
Journal: Frontiers In Cell And Developmental Biology
Abstract: The prevalence of chronic kidney disease (CKD) is rapidly increasing over the last few decades, owing to the global increase in diabetes, and cardiovascular diseases. Dialysis greatly compromises the life quality of patients, while demand for transplantable kidney cannot be met, underscoring the need to develop novel therapeutic approaches to stop or reverse CKD progression. Our understanding of kidney disease is primarily derived from studies using animal models and cell culture. While cross-species differences made it challenging to fully translate findings from animal models into clinical practice, primary patient cells quickly lose the original phenotypes during in vitro culture. Over the last decade, remarkable achievements have been made for generating 3-dimensional (3D) miniature organs (organoids) by exposing stem cells to culture conditions that mimic the signaling cues required for the development of a particular organ or tissue. 3D kidney organoids have been successfully generated from different types of source cells, including human pluripotent stem cells (hPSCs), adult/fetal renal tissues, and kidney cancer biopsy. Alongside gene editing tools, hPSC-derived kidney organoids are being harnessed to model genetic kidney diseases. In comparison, adult kidney-derived tubuloids and kidney cancer-derived tumoroids are still in their infancy. Herein, we first summarize the currently available kidney organoid models. Next, we discuss recent advances in kidney disease modelling using organoid models. Finally, we consider the major challenges that have hindered the application of kidney organoids in disease modelling and drug evaluation and propose prospective solutions.
ISSN: 2296-634X
DOI: 10.3389/fcell.2022.845401
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2022 Liu, Cardilla, Ngeow, Gong and Xia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

Files in This Item:
File Description SizeFormat 
fcell-10-845401.pdf1.14 MBAdobe PDFThumbnail

Citations 50

Updated on Sep 26, 2023

Web of ScienceTM
Citations 50

Updated on Sep 26, 2023

Page view(s)

Updated on Oct 3, 2023

Download(s) 50

Updated on Oct 3, 2023

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.