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Title: Thermodynamic modeling of solvent-assisted lipid bilayer formation process
Authors: Xu, Hongmei
Tae, Hyunhyuk
Cho, Nam-Joon
Huang, Changjin
Hsia, K. Jimmy
Keywords: Engineering::Mechanical engineering
Issue Date: 2022
Source: Xu, H., Tae, H., Cho, N., Huang, C. & Hsia, K. J. (2022). Thermodynamic modeling of solvent-assisted lipid bilayer formation process. Micromachines, 13(1), 134-.
Project: TIER1-2020-T1-002-032
SUG M4082428.050
SUG M4082352.050
Journal: Micromachines
Abstract: The solvent-assisted lipid bilayer (SALB) formation method provides a simple and efficient, microfluidic-based strategy to fabricate supported lipid bilayers (SLBs) with rich compositional diversity on a wide range of solid supports. While various studies have been performed to characterize SLBs formed using the SALB method, relatively limited work has been carried out to understand the underlying mechanisms of SALB formation under various experimental conditions. Through thermodynamic modeling, we studied the experimental parameters that affect the SALB formation process, including substrate surface properties, initial lipid concentration, and temperature. It was found that all the parameters are critically important to successfully form high-quality SLBs. The model also helps to identify the range of parameter space within which conformal, homogeneous SLBs can be fabricated, and provides mechanistic guidance to optimize experimental conditions for lipid membrane-related applications.
ISSN: 2072-666X
DOI: 10.3390/mi13010134
Schools: School of Mechanical and Aerospace Engineering 
School of Materials Science and Engineering 
School of Chemical and Biomedical Engineering 
Rights: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MAE Journal Articles
MSE Journal Articles
SCBE Journal Articles

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