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Title: Comparing protein adsorption onto alumina and silica nanomaterial surfaces: clues for vaccine adjuvant development
Authors: Park, Hyeonjin
Ma, Gamaliel Junren
Yoon, Bo Kyeong
Cho, Nam-Joon
Jackman, Joshua A.
Keywords: Engineering::Materials
Issue Date: 2021
Source: Park, H., Ma, G. J., Yoon, B. K., Cho, N. & Jackman, J. A. (2021). Comparing protein adsorption onto alumina and silica nanomaterial surfaces: clues for vaccine adjuvant development. Langmuir, 37(3), 1306-1314.
Journal: Langmuir
Abstract: Protein adsorption onto nanomaterial surfaces is important for various nanobiotechnology applications such as biosensors and drug delivery. Within this scope, there is growing interest to develop alumina- and silica-based nanomaterial vaccine adjuvants and an outstanding need to compare protein adsorption onto alumina- and silica-based nanomaterial surfaces. Herein, using alumina- and silica-coated arrays of silver nanodisks with plasmonic properties, we conducted localized surface plasmon resonance (LSPR) experiments to evaluate real-time adsorption of bovine serum albumin (BSA) protein onto alumina and silica surfaces. BSA monomers and oligomers were prepared in different water-ethanol mixtures and both adsorbing species consistently showed quicker adsorption kinetics and more extensive adsorption-related spreading on alumina surfaces as compared to on silica surfaces. We rationalized these experimental observations in terms of the electrostatic forces governing protein-surface interactions on the two nanomaterial surfaces and the results support that more rigidly attached BSA protein-based coatings can be formed on alumina-based nanomaterial surfaces. Collectively, the findings in this study provide fundamental insight into protein-surface interactions at nanomaterial interfaces and can help to guide the development of protein-based coatings for medical and biotechnology applications such as vaccines.
ISSN: 0743-7463
DOI: 10.1021/acs.langmuir.0c03396
Schools: School of Materials Science and Engineering 
Rights: © 2021 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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