Please use this identifier to cite or link to this item:
Title: Antibiofilm activity of gallium(III) complexed anionic polymers in combination with antibiotics
Authors: Ma, Jielin
Hou, Shuai
Chan-Park, Mary B.
Duan, Hongwei
Keywords: Engineering::Bioengineering
Issue Date: 2021
Source: Ma, J., Hou, S., Chan-Park, M. B. & Duan, H. (2021). Antibiofilm activity of gallium(III) complexed anionic polymers in combination with antibiotics. Macromolecular Rapid Communications, 42(20), 2100255-.
Project: RG45/18
Journal: Macromolecular Rapid Communications 
Abstract: Pseudomonas aeruginosa (P. aeruginosa) is a life-threatening pathogen associated with multiantibiotic resistance, which is largely caused by its strong ability to form biofilms. Recent research has revealed that gallium (III) shows an activity against the biofilm of P. aeruginosa by interfering with Fe metabolism. The antibacterial activity of the combination of Ga3+ ion and antibiotic rifampicin (RMP) against P. aeruginosa PAO1 is investigated. An anionic polymer poly{{2-[(2-methylprop-2-enoyl)oxy]ethyl}phosphonic acid} (PDMPOH) is exploited to form complexes (GaPD) with Ga3+ . The GaPD complexes act as a carrier of Ga3+ and release Ga3+ via enzymatic degradation by bacterial lipases. GaPD is found to damage the outer membrane, leading to enhanced cellular uptake of RMP and Ga3+ due to increased outer membrane permeability, which inhibits the RNA polymerase and interferes with Fe metabolism. The antibiofilm activity and biocompatibility of the GaPD system offer a promising treatment option for P. aeruginosa biofilm-related infections.
ISSN: 1022-1336
DOI: 10.1002/marc.202100255
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2021 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

Citations 50

Updated on Dec 4, 2023

Web of ScienceTM
Citations 50

Updated on Oct 24, 2023

Page view(s)

Updated on Dec 4, 2023

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.