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Title: Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis
Authors: Teo, Yi Juan
Ng, See Liang
Mak, Keng Wai
Setiagani, Yolanda Aphrilia
Chen, Qi
Nair, Sajith Kumar
Sheng, Jianpeng
Ruedl, Christiane
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Teo, Y. J., Ng, S. L., Mak, K. W., Setiagani, Y. A., Chen, Q., Nair, S. K., Sheng, J. & Ruedl, C. (2021). Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis. Life Science Alliance, 4(5), e202000890-.
Project: MOE2016-T2-1-012 
Journal: Life science alliance 
Abstract: Disseminated candidiasis remains as the most common hospital-acquired bloodstream fungal infection with up to 40% mortality rate despite the advancement of medical and hygienic practices. While it is well established that this infection heavily relies on the innate immune response for host survival, much less is known for the protective role elicited by the tissue-resident macrophage (TRM) subsets in the kidney, the prime organ for Candida persistence. Here, we describe a unique CD169++ TRM subset that controls Candida growth and inflammation during acute systemic candidiasis. Their absence causes severe fungal-mediated renal pathology. CD169++ TRMs, without being actively involved in direct fungal clearance, increase host resistance by promoting IFN-γ release and neutrophil ROS activity.
ISSN: 2575-1077
DOI: 10.26508/lsa.202000890
Schools: School of Biological Sciences 
Rights: © 2021 Teo et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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