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dc.contributor.authorKarabacak, Soneren_US
dc.contributor.authorPalaniappan, Alagappanen_US
dc.contributor.authorTsang, Tony Siu Honen_US
dc.contributor.authorTeo, Edwin Hang Tongen_US
dc.contributor.authorGulyás, Balázsen_US
dc.contributor.authorPadmanabhan, Parasuramanen_US
dc.contributor.authorYildiz, Ümit Hakanen_US
dc.identifier.citationKarabacak, S., Palaniappan, A., Tsang, T. S. H., Teo, E. H. T., Gulyás, B., Padmanabhan, P. & Yildiz, Ü. H. (2022). Gadolinium and polythiophene functionalized polyurea polymer dots as fluoro-magnetic nanoprobes. Nanomaterials, 12(4), 642-.
dc.description.abstractA rapid and one-pot synthesis of poly 3-thiopheneacetic acid (PTAA) functionalized polyurea polymer dots (Pdots) using polyethyleneimine and isophorone diisocyanate is reported. The one-pot mini-emulsion polymerization technique yielded Pdots with an average diameter of ~20 nm. The size, shape, and concentration of the surface functional groups could be controlled by altering the synthesis parameters such as ultrasonication time, concentration of the surfactant, and crosslinking agent, and the types of isocyanates utilized for the synthesis. Colloidal properties of Pdots were characterized using dynamic light scattering and zeta potential measurements. The spherical geometry of Pdots was confirmed by scanning electron microscopy. The Pdots were post-functionalized by 1,4,7,10 tetraazacyclododecane-1,4,7,10-tetraacetic acid for chelating gadolinium nanoparticles (Gd3+) that provide magnetic properties to the Pdots. Thus, the synthesized Pdots possess fluorescent and magnetic properties, imparted by PTAA and Gd3+, respectively. Fluorescence spectroscopy and microscopy revealed that the synthesized dual-functional Gd3+-Pdots exhibited detectable fluorescent signals even at lower concentrations. Magnetic levitation experiments indicated that the Gd3+-Pdots could be easily manipulated via an external magnetic field. These findings illustrate that the dua- functional Gd3+-Pdots could be potentially utilized as fluorescent reporters that can be magnetically manipulated for bioimaging applications.en_US
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/).en_US
dc.titleGadolinium and polythiophene functionalized polyurea polymer dots as fluoro-magnetic nanoprobesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen_US
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.contributor.researchCognitive Neuroimaging Centreen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsDual-Functional Reportersen_US
dc.subject.keywordsPolymer Dotsen_US
dc.description.acknowledgementThis work was supported by The Scientific and Technological Research Council of Turkey, TUBITAK Projects 116Z547 and 120Z588. Author S.K. is YOK 100–2000 scholarship holder.en_US
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