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Title: Gadolinium and polythiophene functionalized polyurea polymer dots as fluoro-magnetic nanoprobes
Authors: Karabacak, Soner
Palaniappan, Alagappan
Tsang, Tony Siu Hon
Teo, Edwin Hang Tong
Gulyás, Balázs
Padmanabhan, Parasuraman
Yildiz, Ümit Hakan
Keywords: Engineering::Materials
Issue Date: 2022
Source: Karabacak, S., Palaniappan, A., Tsang, T. S. H., Teo, E. H. T., Gulyás, B., Padmanabhan, P. & Yildiz, Ü. H. (2022). Gadolinium and polythiophene functionalized polyurea polymer dots as fluoro-magnetic nanoprobes. Nanomaterials, 12(4), 642-.
Journal: Nanomaterials 
Abstract: A rapid and one-pot synthesis of poly 3-thiopheneacetic acid (PTAA) functionalized polyurea polymer dots (Pdots) using polyethyleneimine and isophorone diisocyanate is reported. The one-pot mini-emulsion polymerization technique yielded Pdots with an average diameter of ~20 nm. The size, shape, and concentration of the surface functional groups could be controlled by altering the synthesis parameters such as ultrasonication time, concentration of the surfactant, and crosslinking agent, and the types of isocyanates utilized for the synthesis. Colloidal properties of Pdots were characterized using dynamic light scattering and zeta potential measurements. The spherical geometry of Pdots was confirmed by scanning electron microscopy. The Pdots were post-functionalized by 1,4,7,10 tetraazacyclododecane-1,4,7,10-tetraacetic acid for chelating gadolinium nanoparticles (Gd3+) that provide magnetic properties to the Pdots. Thus, the synthesized Pdots possess fluorescent and magnetic properties, imparted by PTAA and Gd3+, respectively. Fluorescence spectroscopy and microscopy revealed that the synthesized dual-functional Gd3+-Pdots exhibited detectable fluorescent signals even at lower concentrations. Magnetic levitation experiments indicated that the Gd3+-Pdots could be easily manipulated via an external magnetic field. These findings illustrate that the dua- functional Gd3+-Pdots could be potentially utilized as fluorescent reporters that can be magnetically manipulated for bioimaging applications.
ISSN: 2079-4991
DOI: 10.3390/nano12040642
Schools: School of Materials Science and Engineering 
School of Electrical and Electronic Engineering 
Lee Kong Chian School of Medicine (LKCMedicine) 
Research Centres: Cognitive Neuroimaging Centre
Rights: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles
LKCMedicine Journal Articles
MSE Journal Articles
TL Journal Articles

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