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Title: Streamlined fabrication of hybrid lipid bilayer membranes on titanium oxide surfaces: a comparison of one- and two-tail SAM molecules
Authors: Sut, Tun Naw
Tan, Sue Woon
Jeon, Won-Yong
Yoon, Bo Kyeong
Cho, Nam-Joon
Jackman, Joshua A.
Keywords: Engineering::Materials
Issue Date: 2022
Source: Sut, T. N., Tan, S. W., Jeon, W., Yoon, B. K., Cho, N. & Jackman, J. A. (2022). Streamlined fabrication of hybrid lipid bilayer membranes on titanium oxide surfaces: a comparison of one- and two-tail SAM molecules. Nanomaterials, 12(7), 1153-.
Journal: Nanomaterials 
Abstract: There is broad interest in fabricating cell-membrane-mimicking, hybrid lipid bilayer (HLB) coatings on titanium oxide surfaces for medical implant and drug delivery applications. However, existing fabrication strategies are complex, and there is an outstanding need to develop a streamlined method that can be performed quickly at room temperature. Towards this goal, herein, we characterized the room-temperature deposition kinetics and adlayer properties of one- and two-tail phosphonic acid-functionalized molecules on titanium oxide surfaces in various solvent systems and identified optimal conditions to prepare self-assembled monolayers (SAMs), upon which HLBs could be formed in select cases. Among the molecular candidates, we identified a two-tail molecule that formed a rigidly attached SAM to enable HLB fabrication via vesicle fusion for membrane-based biosensing applications. By contrast, vesicles adsorbed but did not rupture on SAMs composed of one-tail molecules. Our findings support that two-tail phosphonic acid SAMs offer superior capabilities for rapid HLB coating fabrication at room temperature, and these streamlined capabilities could be useful to prepare durable lipid bilayer coatings on titanium-based materials.
ISSN: 2079-4991
DOI: 10.3390/nano12071153
Schools: School of Materials Science and Engineering 
Rights: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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