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Title: Second near-infrared light-activatable polymeric nanoantagonist for photothermal immunometabolic cancer therapy
Authors: Xu, Cheng
Jiang, Yuyan
Huang, Jingsheng
Huang, Jiaguo
Pu, Kanyi
Keywords: Engineering::Chemical engineering
Issue Date: 2021
Source: Xu, C., Jiang, Y., Huang, J., Huang, J. & Pu, K. (2021). Second near-infrared light-activatable polymeric nanoantagonist for photothermal immunometabolic cancer therapy. Advanced Materials, 33(36), 2101410-.
Project: 2019-T1-002-045 
Journal: Advanced Materials 
Abstract: Immunometabolic modulation offers new opportunities to treat cancers as it is highly associated with cancer progression and immunosuppressive microenvironment. However, traditional regimens using nonselective small-molecule immunomodulators lead to the off-target adverse effects and insufficient therapeutic outcomes. Herein a second near-infrared (NIR-II) photothermally activatable semiconducting polymeric nanoantagonist (ASPA) for synergistic photothermal immunometabolic therapy of cancer is reported. ASPA backbone is obtained by conjugating vipadenant, an antagonist to adenosine A2A receptor, onto NIR-II light-absorbing semiconducting polymer via an azo-based thermolabile linker. Under deep-penetrating NIR-II photoirradiation, ASPA induces tumor thermal ablation and subsequently immunogenic cell death, triggers the cleavage of thermolabile linker, and releases the antagonist to block the immunosuppressive adenosinergic pathway. Such a remotely controlled immunometabolic regulation potentiates cytotoxic T cell functions while suppresses regulatory T cell activities, leading to efficient primary tumor inhibition, pulmonary metastasis prevention, and long-term immunological memory. Thereby, this work provides a generic polymeric approach for precise spatiotemporal regulation of cancer immunometabolism.
ISSN: 0935-9648
DOI: 10.1002/adma.202101410
Schools: School of Chemical and Biomedical Engineering 
School of Physical and Mathematical Sciences 
Rights: © 2021 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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