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Title: Activatable polymer nanoenzymes for photodynamic immunometabolic cancer therapy
Authors: Zeng, Ziling
Zhang, Chi
Li, Jingchao
Cui, Dong
Jiang, Yuyan
Pu, Kanyi
Keywords: Engineering::Bioengineering
Issue Date: 2021
Source: Zeng, Z., Zhang, C., Li, J., Cui, D., Jiang, Y. & Pu, K. (2021). Activatable polymer nanoenzymes for photodynamic immunometabolic cancer therapy. Advanced Materials, 33(4), 2007247-.
Project: M4081627.120
Journal: Advanced Materials
Abstract: Tumor immunometabolism contributes substantially to tumor proliferation and immune cell activity, and thus plays a crucial role in the efficacy of cancer immunotherapy. Modulation of immunometabolism to boost cancer immunotherapy is mostly based on small-molecule inhibitors, which often encounter the issues of off-target adverse effects, drug resistance, and unsustainable response. In contrast, enzymatic therapeutics can potentially bypass these limitations but has been less exploited. Herein, an organic polymer nanoenzyme (SPNK) with near-infrared (NIR) photoactivatable immunotherapeutic effects is reported for photodynamic immunometabolic therapy. SPNK is composed of a semiconducting polymer core conjugated with kynureninase (KYNase) via PEGylated singlet oxygen (1 O2 ) cleavable linker. Upon NIR photoirradiation, SPNK generates 1 O2 not only to exert photodynamic effect to induce the immunogenic cell death of cancer, but also to unleash KYNase and trigger its activity to degrade the immunosuppressive kynurenine (Kyn). Such a combinational effect mediated by SPNK promotes the proliferation and infiltration of effector T cells, enhances systemic antitumor T cell immunity, and ultimately permits inhibition of both primary and distant tumors in living mice. Therefore, this study provides a promising photodynamic approach toward remotely controlled enzymatic immunomodulation for improved anticancer therapy.
ISSN: 0935-9648
DOI: 10.1002/adma.202007247
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2020 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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