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Title: Second near-infrared photothermal semiconducting polymer nanoadjuvant for enhanced cancer immunotherapy
Authors: Li, Jingchao
Yu, Xiangrong
Jiang, Yuyan
He, Shasha
Zhang, Yan
Luo, Yu
Pu, Kanyi
Keywords: Engineering::Chemical engineering
Issue Date: 2021
Source: Li, J., Yu, X., Jiang, Y., He, S., Zhang, Y., Luo, Y. & Pu, K. (2021). Second near-infrared photothermal semiconducting polymer nanoadjuvant for enhanced cancer immunotherapy. Advanced Materials, 33(4), 2003458-.
Project: M4081627.120
Journal: Advanced Materials
Abstract: Immunotherapy has offered new treatment options for cancer; however, the therapeutic benefits are often modest and desired to be improved. A semiconducting polymer nanoadjuvant (SPNII R) with a photothermally triggered cargo release for second near-infrared (NIR-II) photothermal immunotherapy is reported here. SPNII R consists of a semiconducting polymer nanoparticle core as an NIR-II photothermal converter, which is doped with a toll-like receptor (TLR) agonist as an immunotherapy adjuvant and coated with a thermally responsive lipid shell. Upon NIR-II photoirradiation, SPNII R effectively generates heat not only to ablate tumors and induce immunogenic cell death (ICD), but also to melt the lipid layers for on-demand release of the TLR agonist. The combination of ICD and activation of TLR7/TLR8 enhances the maturation of dendritic cells, which amplifies anti-tumor immune responses. Thus, a single treatment of SPNII R-mediated NIR-II photothermal immunotherapy effectively inhibits growth of both primary and distant tumors and eliminates lung metastasis in a murine mouse model. This study thus provides a remote-controlled smart delivery system to synergize photomedicine with immunotherapy for enhanced cancer treatment.
ISSN: 0935-9648
DOI: 10.1002/adma.202003458
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2020 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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