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Title: Sustainable aquaculture side-streams derived hybrid biocomposite for bone tissue engineering
Authors: Wang, Jun Kit 
Cimenoglu, Cigdem
Cheam, Nicole Mein Ji
Hu, Xiao
Tay, Chor Yong
Keywords: Engineering::Materials
Issue Date: 2021
Source: Wang, J. K., Cimenoglu, C., Cheam, N. M. J., Hu, X. & Tay, C. Y. (2021). Sustainable aquaculture side-streams derived hybrid biocomposite for bone tissue engineering. Materials Science and Engineering: C, 126, 112104-.
Project: RG38/20 2020-T1-001-152
Journal: Materials Science and Engineering: C
Abstract: Despite being a rich source of bioactive compounds, the current exploitation of aquatic biomass is insufficient. Majority of the aquaculture industry side-streams are currently used for low-value purposes such as animal feed or composting material, with low economical returns. To maximize resource reuse and minimize waste generation, valorization efforts should be augmented with the aim to produce high-value products. Herein, we present a novel aquaculture wastes-derived multi-scale osteoconductive hybrid biocomposite that is composed of chemically crosslinked American bullfrog (Rana catesbeiana) skin-derived type I tropocollagen nanofibrils (~22.3 nm) network and functionalized with micronized (~1.6 μm) single-phase hydroxyapatite (HA) from discarded snakehead (Channa micropeltes) fish scales. The bioengineered construct is biocompatible, highly porous (>90%), and exhibits excellent osteoconductive properties, as indicated by robust adhesion and proliferation of human fetal osteoblastic 1.19 cell line (hFOB 1.19). Furthermore, increased expression level of osteo-related ALPL and BGLAP mRNA transcripts, as well as enhanced osteocalcin immunoreactivity and increasing Alizarin red S staining coverage on the hybrid biocomposite was observed over 21 days of culture. Collectively, the devised "waste-to-resource" platform represents a sustainable waste valorization strategy that is amendable for advanced bone repair and regeneration applications.
ISSN: 0928-4931
DOI: 10.1016/j.msec.2021.112104
Schools: School of Materials Science and Engineering 
School of Biological Sciences 
Research Centres: Nanyang Environment and Water Research Institute 
Energy Research Institute @ NTU (ERI@N) 
Rights: © 2021 Elsevier B.V. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:ERI@N Journal Articles
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