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Title: Gold-modified paper as microfluidic substrates with reduced biofouling in potentiometric ion sensing
Authors: Ding, Ruiyu
Joon, Narender Kumar
Ahamed, Ashiq
Shafaat, Atefeh
Guzinski, Marcin
Wagner, Michal
Ruzgas, Tautgirdas
Bobacka, Johan
Lisak, Grzegorz
Keywords: Engineering::Environmental engineering
Issue Date: 2021
Source: Ding, R., Joon, N. K., Ahamed, A., Shafaat, A., Guzinski, M., Wagner, M., Ruzgas, T., Bobacka, J. & Lisak, G. (2021). Gold-modified paper as microfluidic substrates with reduced biofouling in potentiometric ion sensing. Sensors and Actuators B: Chemical, 344, 130200-.
Journal: Sensors and Actuators B: Chemical
Abstract: Microfluidic sampling media based on paper and its modifications with either gold nanoparticles or sputtered gold were evaluated for potentiometric determination of Na+, K+, and Cl– ions in clinically relevant samples. The measurements were conducted in comparison to other commonly considered microfluidic substrates, i.e. sponge, polyester textile, and polyamide textile. Ion determination was done by using solid-contact ion-selective electrodes based on plasticized PVC membranes for Na+, K+, and Cl– ions and utilizing PEDOT(PSS) or PEDOT(Cl) as the ion-to-electron transducer. The solid-contact ion-selective electrodes and a solid-state reference electrode were placed directly on the substrate into which the sample solution was wicked. Transport of bovine serum albumin (BSA) through the paper substrate was studied by ellipsometry. Modification of the paper substrates by gold nanoparticles (AuNPs) was found to slow down the transport of BSA through the paper, when compared with unmodified paper substrates and when compared with all the other alternative sampling matrices studied. The retention of BSA obtained with AuNP-modified paper substrates significantly improved the accuracy of the potentiometric ion determinations in sweat, saliva, artificial tears, and artificial serum. The potentiometric results were validated by inductively coupled plasma optical emission spectrometry (ICP-OES) and ion chromatography (IC). The study indicates that modification of paper by AuNPs is a feasible approach to reduce biofouling of sensors that are used in the paper-based analysis of clinically relevant samples.
ISSN: 0925-4005
DOI: 10.1016/j.snb.2021.130200
Schools: School of Civil and Environmental Engineering 
Research Centres: Residues and Resource Reclamation Centre 
Nanyang Environment and Water Research Institute 
Rights: © 2021 Elsevier B.V. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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