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Title: A metabolic labeling way to in situ fabricate bacterial FRET platform for innate immune defence molecule
Authors: Zhang, Zhijun
Han, Qinyu
Lau, Junwei
Wang, Zhimin
Hu, Ming
Qiu, Hao
Thang, Do Cong
Xing, Bengang
Keywords: Science::Chemistry
Issue Date: 2022
Source: Zhang, Z., Han, Q., Lau, J., Wang, Z., Hu, M., Qiu, H., Thang, D. C. & Xing, B. (2022). A metabolic labeling way to in situ fabricate bacterial FRET platform for innate immune defence molecule. Sensors and Actuators B: Chemical, 350, 130913-.
Project: RG5/18 (S)
MOE 2017-T2–2-110
A1983c0028 (M4070319)
Journal: Sensors and Actuators B: Chemical
Abstract: A simple and unique bacterial fluorescence resonance energy transfer (FRET) platform is developed through metabolic biosynthetic pathways for the sensitive and ratiometric detection of innate immune defence molecule. Using this bacterial FRET platform, immune molecule lysozyme could be sensitively monitored in buffer, in serum, and even in the secretion of infected immune cells. As an important defensive molecule of the innate immune system, lysozyme not only plays a significant role in mediating protection against microbial invasion, but also acts as a significant biomarker of leukemia, tuberculosis, meningitis and renal diseases. Considering the importance of perceiving lysozyme activity, this work sheds a light on the access of host's immune response of bacterial infection, as well as provides valuable guidance for the treatment of bacterial infection related diseases.
ISSN: 0925-4005
DOI: 10.1016/j.snb.2021.130913
Schools: School of Physical and Mathematical Sciences 
School of Chemical and Biomedical Engineering 
Rights: © 2021 Elsevier B.V. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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