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Title: Biocompatible ionic liquids in high-performing organic electrochemical transistors for ion detection and electrophysiological monitoring
Authors: Li, Ting
Koh, Cheryl Jie Yan
Moudgil, Akshay
Cao, Huan
Wu, Xihu
Chen, Shuai
Hou, Kunqi
Surendran, Abhijith
Stephen, Meera
Tang, Cindy
Wang, Chongwu
Wang, Qi Jie
Tay, Chor Yong
Leong, Wei Lin 
Keywords: Engineering::Electrical and electronic engineering
Engineering::Materials::Microelectronics and semiconductor materials
Engineering::Materials::Organic/Polymer electronics
Issue Date: 2022
Source: Li, T., Koh, C. J. Y., Moudgil, A., Cao, H., Wu, X., Chen, S., Hou, K., Surendran, A., Stephen, M., Tang, C., Wang, C., Wang, Q. J., Tay, C. Y. & Leong, W. L. (2022). Biocompatible ionic liquids in high-performing organic electrochemical transistors for ion detection and electrophysiological monitoring. ACS Nano.
Project: MOE2019-T2-2-106 
Journal: ACS Nano 
Abstract: Organic electrochemical transistors (OECTs) have recently attracted attention due to their high transconductance and low operating voltage, which makes them ideal for a wide range of biosensing applications. Poly-3,4-ethylenedioxythiophene:poly-4-styrenesulfonate (PEDOT:PSS) is a typical material used as the active channel layer in OECTs. Pristine PEDOT:PSS has poor electrical conductivity and additives are typically introduced to improve its conductivity and OECT performance. However, these additives are mostly either toxic or not proved to be biocompatible. Herein, a biocompatible ionic liquid [MTEOA][MeOSO3] is demonstrated to be an effective additive to enhance the performance of PEDOT:PSS based OECTs. The influence of [MTEOA][MeOSO3] on the conductivity, morphology and the redox process of PEDOT:PSS are investigated. The PEDOT:PSS/[MTEOA][MeOSO3] based OECT exhibits high transconductance (22.3 ± 4.5 mS μm-1), high μC* (the product of mobility μ and volumetric capacitance C*) (283.80 ± 29.66 F cm-1 V-1 s-1), fast response time (~40.57 μs) and excellent switching cyclical stability. Next, the integration of sodium (Na+) and potassium (K+) ion-selective membranes with the OECTs is demonstrated, enabling selective ions detection in the physiological range. In addition, flexible OECTs are designed for electrophysiological (ECG) signals acquisition. These OECTs have shown robust performance against physical deformation and successfully recorded high quality ECG signals.
ISSN: 1936-0851
DOI: 10.1021/acsnano.2c02191
DOI (Related Dataset): 10.21979/N9/SAJEX0
Schools: School of Electrical and Electronic Engineering 
School of Materials Science and Engineering 
School of Physical and Mathematical Sciences 
School of Biological Sciences 
Research Centres: Environmental Chemistry And Materials Centre
Nanyang Environment and Water Research Institute 
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Nano, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
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