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dc.contributor.authorTae, Hyunhyuken_US
dc.contributor.authorPark, Soohyunen_US
dc.contributor.authorMa, Gamaliel Junrenen_US
dc.contributor.authorCho, Nam-Joonen_US
dc.identifier.citationTae, H., Park, S., Ma, G. J. & Cho, N. (2022). Nanoarchitectured air-stable supported lipid bilayer incorporating sucrose-bicelle complex system. Nano Convergence, 9(1), 3-.
dc.description.abstractCell-membrane-mimicking supported lipid bilayers (SLBs) provide an ultrathin, self-assembled layer that forms on solid supports and can exhibit antifouling, signaling, and transport properties among various possible functions. While recent material innovations have increased the number of practically useful SLB fabrication methods, typical SLB platforms only work in aqueous environments and are prone to fluidity loss and lipid-bilayer collapse upon air exposure, which limits industrial applicability. To address this issue, herein, we developed sucrose-bicelle complex system to fabricate air-stable SLBs that were laterally mobile upon rehydration. SLBs were fabricated from bicelles in the presence of up to 40 wt% sucrose, which was verified by quartz crystal microbalance-dissipation (QCM-D) and fluorescence recovery after photobleaching (FRAP) experiments. The sucrose fraction in the system was an important factor; while 40 wt% sucrose induced lipid aggregation and defects on SLBs after the dehydration-rehydration process, 20 wt% sucrose yielded SLBs that exhibited fully recovered lateral mobility after these processes. Taken together, these findings demonstrate that sucrose-bicelle complex system can facilitate one-step fabrication of air-stable SLBs that can be useful for a wide range of biointerfacial science applications.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.relation2020-T1-002-032 (RG111/20)en_US
dc.relation.ispartofNano Convergenceen_US
dc.rights© 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit
dc.titleNanoarchitectured air-stable supported lipid bilayer incorporating sucrose-bicelle complex systemen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsSupported Lipid Bilayeren_US
dc.description.acknowledgementThis work was supported by the Ministry of Education (MOE) in Singapore under Grant AcRF TIER1-2020-T1-002-032 (RG111/20). This work was also sup‑ ported by the China-Singapore International Joint Research Institute (CSIJRI). HT is supported by a SINGA graduate scholarship from the A*STAR Graduate Academy, Singapore.en_US
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