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dc.contributor.authorDing, Mengbinen_US
dc.contributor.authorZhang, Yijingen_US
dc.contributor.authorLi, Jingchaoen_US
dc.contributor.authorPu, Kanyien_US
dc.identifier.citationDing, M., Zhang, Y., Li, J. & Pu, K. (2022). Bioenzyme-based nanomedicines for enhanced cancer therapy. Nano Convergence, 9(1), 7-.
dc.description.abstractBioenzymes that catalyze reactions within living systems show a great promise for cancer therapy, particularly when they are integrated with nanoparticles to improve their accumulation into tumor sites. Nanomedicines can deliver toxic bioenzymes into cancer cells to directly cause their death for cancer treatment. By modulating the tumor microenvironment, such as pH, glucose concentration, hypoxia, redox levels and heat shock protein expression, bioenzyme-based nanomedicines play crucial roles in improving the therapeutic efficacy of treatments. Moreover, bioenzyme-mediated degradation of the major components in tumor extracellular matrix greatly increases the penetration and retention of nanoparticles in deep tumors and infiltration of immune cells into tumor tissues, thus enhancing the efficacies of chemotherapy, phototherapy and immunotherapy. In this review, we summarize the recent progresses of bioenzyme-based nanomedicines for enhanced cancer therapy. The design and working mechanisms of the bioenzyme-based nanomedicines to achieve enhanced chemotherapy, photothermal therapy, photodynamic therapy, chemodynamic therapy, radiotherapy and immunotherapy are introduced in detail. At the end of this review, a conclusion and current challenges and perspectives in this field are given.en_US
dc.relation.ispartofNano Convergenceen_US
dc.rights© 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit
dc.subjectEngineering::Chemical engineeringen_US
dc.titleBioenzyme-based nanomedicines for enhanced cancer therapyen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.versionPublished versionen_US
dc.description.acknowledgementThis study was supported by the Fundamental Research Funds for the Central Universities (2232021A-05), Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, Science and Technology Commission of Shanghai Municipality (20DZ2254900).en_US
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