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Title: Cellular features revealed by transverse laser modes in frequency domain
Authors: Qiao, Zhen
Xu, Hongmei
Zhang, Na
Gong, Xuerui
Gong, Chaoyang
Yang, Guang
Chew, Sing Yian
Huang, Changjin
Chen, Yu-Cheng
Keywords: Engineering::Electrical and electronic engineering
Issue Date: 2022
Source: Qiao, Z., Xu, H., Zhang, N., Gong, X., Gong, C., Yang, G., Chew, S. Y., Huang, C. & Chen, Y. (2022). Cellular features revealed by transverse laser modes in frequency domain. Advanced Science, 9(1), 2103550-.
Project: A2084c0063
Journal: Advanced Science 
Abstract: Biological lasers which utilize Fabry-Pérot (FP) cavities have attracted tremendous interest due to their potential in amplifying subtle biological changes. Transverse laser modes generated from cells serve as distinct fingerprints of individual cells; however, most lasing signals lack the ability to provide key information about the cell due to high complexity of transverse modes. The missing key, therefore, hinders it from practical applications in biomedicine. This study reveals the key mechanism governing the frequency distributions of transverse modes in cellular lasers. Spatial information of cells including curvature can be interpreted through spectral information of transverse modes by means of hyperspectral imaging. Theoretical studies are conducted to explore the correlation between the cross-sectional morphology of a cell and lasing frequencies of transverse modes. Experimentally, the spectral characteristics of transverse modes are investigated in live and fixed cells with different morphological features. By extracting laser modes in frequency domain, the proposed concept is applied for studying cell adhesion process and cell classification from rat cortices. This study expands a new analytical dimension of cell lasers, opening an avenue for subcellular analysis in biophotonic applications.
ISSN: 2198-3844
DOI: 10.1002/advs.202103550
Schools: School of Electrical and Electronic Engineering 
School of Mechanical and Aerospace Engineering 
School of Chemical and Biomedical Engineering 
Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2021 The Authors. Advanced Science published by Wiley-VCH GmbH.This is an open access article under the terms of the Creative CommonsAttribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles
LKCMedicine Journal Articles
MAE Journal Articles
SCBE Journal Articles

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