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Title: Cutibacterium acnes: much ado about maybe nothing much
Authors: van Steensel, Maurice A. M.
Chong, Goh Boon
Keywords: Science::Medicine
Issue Date: 2021
Source: van Steensel, M. A. M. & Chong, G. B. (2021). Cutibacterium acnes: much ado about maybe nothing much. Experimental Dermatology, 30(10), 1471-1476.
Project: H17/01/a0/004
Journal: Experimental Dermatology
Abstract: Cutibacterium acnes (also known as Propionibacterium acnes) has long been implicated in the pathogenesis of acne, inspiring both therapeutic and personal care approaches aiming to control the disease by controlling the bacterium. The purported association has made people with acne feel dirty and led to the-at times excessive-use of cleansers, antiseptics and antibiotics for the condition. However, recent evidence seems to weaken the case for C. acnes' involvement. New genetics and molecular biology findings strongly suggest that abnormal differentiation of sebaceous progenitor cells causes comedones, the primary lesions in acne. Comodegenesis is initiated by androgens and is unlikely to be triggered by C. acnes, which probably doesn't affect sebaceous differentiation. Is there still a place for it in this understanding of acne? It is necessary to critically address this question because it has consequences for treatment. Antibiotic use for acne noticeably contributes to microbial drug resistance, which we can ill afford. In this Viewpoint, we explore if and how C. acnes (still) fits into the developing view on acne. We also briefly discuss the implications for therapy in the light of antibiotic resistance and the need for more targeted therapies.
ISSN: 0906-6705
DOI: 10.1111/exd.14394
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: Skin Research Institute of Singapore, A*STAR
Rights: © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

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