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Title: Cellular senescence: mechanisms and therapeutic potential
Authors: Liao, Zehuan
Yeo, Han Lin
Wong, Siaw Wen
Zhao, Yan
Keywords: Science::Biological sciences
Issue Date: 2021
Source: Liao, Z., Yeo, H. L., Wong, S. W. & Zhao, Y. (2021). Cellular senescence: mechanisms and therapeutic potential. Biomedicines, 9(12), 1769-.
Journal: Biomedicines
Abstract: Cellular senescence is a complex and multistep biological process which cells can undergo in response to different stresses. Referring to a highly stable cell cycle arrest, cellular senescence can influence a multitude of biological processes-both physiologically and pathologically. While phenotypically diverse, characteristics of senescence include the expression of the senescence-associated secretory phenotype, cell cycle arrest factors, senescence-associated β-galactosidase, morphogenesis, and chromatin remodelling. Persistent senescence is associated with pathologies such as aging, while transient senescence is associated with beneficial programmes, such as limb patterning. With these implications, senescence-based translational studies, namely senotherapy and pro-senescence therapy, are well underway to find the cure to complicated diseases such as cancer and atherosclerosis. Being a subject of major interest only in the recent decades, much remains to be studied, such as regarding the identification of unique biomarkers of senescent cells. This review attempts to provide a comprehensive understanding of the diverse literature on senescence, and discuss the knowledge we have on senescence thus far.
ISSN: 2227-9059
DOI: 10.3390/biomedicines9121769
Schools: School of Biological Sciences 
School of Chemical and Biomedical Engineering 
Rights: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles
SCBE Journal Articles

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