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Title: Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
Authors: Zhu, Lei
van der Pluijm, Rob W.
Kucharski, Michal
Nayak, Sourav
Tripathi, Jaishree
White, Nicholas J.
Day, Nicholas P. J.
Faiz, Abul
Phyo, Aung Pyae
Amaratunga, Chanaki
Lek, Dysoley
Ashley, Elizabeth A.
Nosten, François
Smithuis, Frank
Ginsburg, Hagai
von Seidlein, Lorenz
Lin, Khin
Imwong, Mallika
Chotivanich, Kesinee
Mayxay, Mayfong
Dhorda, Mehul
Nguyen, Hoang Chau
Nguyen, Thuy Nhien Thanh
Miotto, Olivo
Newton, Paul N.
Jittamala, Podjanee
Tripura, Rupam
Pukrittayakamee, Sasithon
Peto, Thomas J.
Hien, Tran Tinh
Dondorp, Arjen M.
Bozdech, Zbynek
Keywords: Science::Biological sciences
Issue Date: 2022
Source: Zhu, L., van der Pluijm, R. W., Kucharski, M., Nayak, S., Tripathi, J., White, N. J., Day, N. P. J., Faiz, A., Phyo, A. P., Amaratunga, C., Lek, D., Ashley, E. A., Nosten, F., Smithuis, F., Ginsburg, H., von Seidlein, L., Lin, K., Imwong, M., Chotivanich, K., ...Bozdech, Z. (2022). Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response. Communications Biology, 5(1), 274-.
Project: NMRC/OFIRG/0040/2017
MOE2017-T2-2-030 (S)
Journal: Communications Biology
Abstract: The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016-2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodelling, and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex.
ISSN: 2399-3642
DOI: 10.1038/s42003-022-03215-0
Schools: School of Biological Sciences 
Rights: © 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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