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https://hdl.handle.net/10356/160903| Title: | Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response | Authors: | Zhu, Lei van der Pluijm, Rob W. Kucharski, Michal Nayak, Sourav Tripathi, Jaishree White, Nicholas J. Day, Nicholas P. J. Faiz, Abul Phyo, Aung Pyae Amaratunga, Chanaki Lek, Dysoley Ashley, Elizabeth A. Nosten, François Smithuis, Frank Ginsburg, Hagai von Seidlein, Lorenz Lin, Khin Imwong, Mallika Chotivanich, Kesinee Mayxay, Mayfong Dhorda, Mehul Nguyen, Hoang Chau Nguyen, Thuy Nhien Thanh Miotto, Olivo Newton, Paul N. Jittamala, Podjanee Tripura, Rupam Pukrittayakamee, Sasithon Peto, Thomas J. Hien, Tran Tinh Dondorp, Arjen M. Bozdech, Zbynek |
Keywords: | Science::Biological sciences | Issue Date: | 2022 | Source: | Zhu, L., van der Pluijm, R. W., Kucharski, M., Nayak, S., Tripathi, J., White, N. J., Day, N. P. J., Faiz, A., Phyo, A. P., Amaratunga, C., Lek, D., Ashley, E. A., Nosten, F., Smithuis, F., Ginsburg, H., von Seidlein, L., Lin, K., Imwong, M., Chotivanich, K., ...Bozdech, Z. (2022). Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response. Communications Biology, 5(1), 274-. https://dx.doi.org/10.1038/s42003-022-03215-0 | Project: | NMRC/OFIRG/0040/2017 MOE2019-T3-1-007 MOE2017-T2-2-030 (S) |
Journal: | Communications Biology | Abstract: | The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria elimination ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016-2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodelling, and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex. | URI: | https://hdl.handle.net/10356/160903 | ISSN: | 2399-3642 | DOI: | 10.1038/s42003-022-03215-0 | Schools: | School of Biological Sciences | Rights: | © 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | SBS Journal Articles |
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| s42003-022-03215-0.pdf | 3.57 MB | Adobe PDF |  View/Open |
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