Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/160960
Title: Potentials and challenges of Levodopa particle formulation for treatment of Parkinson's disease through intranasal and pulmonary delivery
Authors: Paul, Mahasweta
Lau, Raymond
Keywords: Engineering::Bioengineering
Issue Date: 2020
Source: Paul, M. & Lau, R. (2020). Potentials and challenges of Levodopa particle formulation for treatment of Parkinson's disease through intranasal and pulmonary delivery. Advanced Powder Technology, 31(6), 2357-2365. https://dx.doi.org/10.1016/j.apt.2020.03.028
Journal: Advanced Powder Technology
Abstract: Inhalation drug delivery has gained interests in delivery of Levodopa for the treatment of Parkinson's disease. In comparison to traditional oral delivery, delivery via intranasal or pulmonary pathways allows a slower drug degradation, greater drug bioavailability, increased blood plasma concentrations for longer periods and the ability to bypass the blood brain barrier. This review aims to highlight and summarize the recent advances made in the development of Levodopa particle formulations in terms of its characteristics, production techniques, choice of carrier materials, as well as pharmacokinetics and pharmacodynamics the formulations.
URI: https://hdl.handle.net/10356/160960
ISSN: 0921-8831
DOI: 10.1016/j.apt.2020.03.028
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2020 The Society of Powder Technology Japan. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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