Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/161087
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dc.contributor.authorCheng, Penghuien_US
dc.contributor.authorChen, Wanen_US
dc.contributor.authorLi, Shenhuaen_US
dc.contributor.authorHe, Shashaen_US
dc.contributor.authorMiao, Qingqingen_US
dc.contributor.authorPu, Kanyien_US
dc.date.accessioned2022-08-15T06:05:57Z-
dc.date.available2022-08-15T06:05:57Z-
dc.date.issued2020-
dc.identifier.citationCheng, P., Chen, W., Li, S., He, S., Miao, Q. & Pu, K. (2020). Fluoro-photoacoustic polymeric renal reporter for real-time dual imaging of acute kidney injury. Advanced Materials, 32(17), 1908530-. https://dx.doi.org/10.1002/adma.201908530en_US
dc.identifier.issn0935-9648en_US
dc.identifier.urihttps://hdl.handle.net/10356/161087-
dc.description.abstractPhotoacoustic (PA) imaging agents detect disease tissues and biomarkers with increased penetration depth and enhanced spatial resolution relative to traditional optical imaging, and thus hold great promise for clinical applications. However, existing PA imaging agents often encounter the issues of slow body excretion and low-signal specificity, which compromise their capability for in vivo detection. Herein, a fluoro-photoacoustic polymeric renal reporter (FPRR) is synthesized for real-time imaging of drug-induced acute kidney injury (AKI). FPRR simultaneously turns on both near-infrared fluorescence (NIRF) and PA signals in response to an AKI biomarker (γ-glutamyl transferase) with high sensitivity and specificity. In association with its high renal clearance efficiency (78% at 24 h post-injection), FPRR can detect cisplatin-induced AKI at 24 h post-drug treatment through both real-time imaging and optical urinalysis, which is 48 h earlier than serum biomarker elevation and histological changes. More importantly, the deep-tissue penetration capability of PA imaging results in a signal-to-background ratio that is 2.3-fold higher than NIRF imaging. Thus, the study not only demonstrates the first activatable PA probe for real-time sensitive imaging of kidney function at molecular level, but also highlights the polymeric probe structure with high renal clearance.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.language.isoenen_US
dc.relationM4081627en_US
dc.relation2017-T1-002-134en_US
dc.relationRG147/17en_US
dc.relation2019-T1-002-045en_US
dc.relationRG125/19en_US
dc.relationMOE2018-T2-2-042en_US
dc.relation.ispartofAdvanced Materialsen_US
dc.rights© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.en_US
dc.subjectEngineering::Bioengineeringen_US
dc.titleFluoro-photoacoustic polymeric renal reporter for real-time dual imaging of acute kidney injuryen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.identifier.doi10.1002/adma.201908530-
dc.identifier.pmid32141674-
dc.identifier.scopus2-s2.0-85081400162-
dc.identifier.issue17en_US
dc.identifier.volume32en_US
dc.identifier.spage1908530en_US
dc.subject.keywordsAcute Kidney Injuryen_US
dc.subject.keywordsKidney Imagingen_US
dc.description.acknowledgementK.P. thanks Nanyang Technological University (Start-Up grant: M4081627), Singapore Ministry of Education Academic Research Fund Tier 1 (2017-T1-002-134, RG147/17; 2019-T1-002-045, RG125/19), and Academic Research Fund Tier 2 (MOE2018-T2-2-042) for the financial support. Q.M. thanks National Natural Science Foundation of China (Grant No. 81901803), Jiangsu Specially Appointed Professorship, and Natural Science Foundation of Jiangsu Province (BK20190811).en_US
item.fulltextNo Fulltext-
item.grantfulltextnone-
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