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Title: Fluoro-photoacoustic polymeric renal reporter for real-time dual imaging of acute kidney injury
Authors: Cheng, Penghui
Chen, Wan
Li, Shenhua
He, Shasha
Miao, Qingqing
Pu, Kanyi
Keywords: Engineering::Bioengineering
Issue Date: 2020
Source: Cheng, P., Chen, W., Li, S., He, S., Miao, Q. & Pu, K. (2020). Fluoro-photoacoustic polymeric renal reporter for real-time dual imaging of acute kidney injury. Advanced Materials, 32(17), 1908530-.
Project: M4081627
Journal: Advanced Materials
Abstract: Photoacoustic (PA) imaging agents detect disease tissues and biomarkers with increased penetration depth and enhanced spatial resolution relative to traditional optical imaging, and thus hold great promise for clinical applications. However, existing PA imaging agents often encounter the issues of slow body excretion and low-signal specificity, which compromise their capability for in vivo detection. Herein, a fluoro-photoacoustic polymeric renal reporter (FPRR) is synthesized for real-time imaging of drug-induced acute kidney injury (AKI). FPRR simultaneously turns on both near-infrared fluorescence (NIRF) and PA signals in response to an AKI biomarker (γ-glutamyl transferase) with high sensitivity and specificity. In association with its high renal clearance efficiency (78% at 24 h post-injection), FPRR can detect cisplatin-induced AKI at 24 h post-drug treatment through both real-time imaging and optical urinalysis, which is 48 h earlier than serum biomarker elevation and histological changes. More importantly, the deep-tissue penetration capability of PA imaging results in a signal-to-background ratio that is 2.3-fold higher than NIRF imaging. Thus, the study not only demonstrates the first activatable PA probe for real-time sensitive imaging of kidney function at molecular level, but also highlights the polymeric probe structure with high renal clearance.
ISSN: 0935-9648
DOI: 10.1002/adma.201908530
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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