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Title: A flexi-PEGDA upconversion implant for wireless brain photodynamic therapy
Authors: Teh, Daniel Boon Loong
Bansal, Akshaya
Chai, Chou
Toh, Tan Boon
Tucker, Robert Alan Jappy
Gammad, Gil Gerald Lasam
Yeo, Yanzhuang
Lei, Zhendong
Zheng, Xiang
Yang, Fengyuan
Ho, John S.
Bolem, Nagarjun
Wu, Bing Cheng
Gnanasammandhan, Muthu Kumar
Hooi, Lissa
Dawe, Gavin Stewart
Libedinsky, Camilo
Ong, Wei-Yi
Halliwell, Barry
Chow, Edward Kai-Hua
Lim, Kah-Leong
Zhang, Yong
Kennedy, Brian K.
Keywords: Science::Medicine
Issue Date: 2020
Source: Teh, D. B. L., Bansal, A., Chai, C., Toh, T. B., Tucker, R. A. J., Gammad, G. G. L., Yeo, Y., Lei, Z., Zheng, X., Yang, F., Ho, J. S., Bolem, N., Wu, B. C., Gnanasammandhan, M. K., Hooi, L., Dawe, G. S., Libedinsky, C., Ong, W., Halliwell, B., ...Kennedy, B. K. (2020). A flexi-PEGDA upconversion implant for wireless brain photodynamic therapy. Advanced Materials, 32(29), 2001459-.
Project: R-183-000-413-733
Journal: Advanced Materials 
Abstract: Near-infrared (NIR) activatable upconversion nanoparticles (UCNPs) enable wireless-based phototherapies by converting deep-tissue-penetrating NIR to visible light. UCNPs are therefore ideal as wireless transducers for photodynamic therapy (PDT) of deep-sited tumors. However, the retention of unsequestered UCNPs in tissue with minimal options for removal limits their clinical translation. To address this shortcoming, biocompatible UCNPs implants are developed to deliver upconversion photonic properties in a flexible, optical guide design. To enhance its translatability, the UCNPs implant is constructed with an FDA-approved poly(ethylene glycol) diacrylate (PEGDA) core clad with fluorinated ethylene propylene (FEP). The emission spectrum of the UCNPs implant can be tuned to overlap with the absorption spectra of the clinically relevant photosensitizer, 5-aminolevulinic acid (5-ALA). The UCNPs implant can wirelessly transmit upconverted visible light till 8 cm in length and in a bendable manner even when implanted underneath the skin or scalp. With this system, it is demonstrated that NIR-based chronic PDT is achievable in an untethered and noninvasive manner in a mouse xenograft glioblastoma multiforme (GBM) model. It is postulated that such encapsulated UCNPs implants represent a translational shift for wireless deep-tissue phototherapy by enabling sequestration of UCNPs without compromising wireless deep-tissue light delivery.
ISSN: 0935-9648
DOI: 10.1002/adma.202001459
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
School of Biological Sciences 
Organisations: Yong Loo Lin School of Medicine, National University of Singapore
Rights: © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles
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