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Title: Interpenetrating network of alginate-human adipose extracellular matrix hydrogel for islet cells encapsulation
Authors: Wang, Jun Kit 
Cheam, Nicole Mein Ji
Irvine, Scott Alexander
Tan, Nguan Soon
Venkatraman, Subbu
Tay, Chor Yong
Keywords: Engineering::Materials
Issue Date: 2020
Source: Wang, J. K., Cheam, N. M. J., Irvine, S. A., Tan, N. S., Venkatraman, S. & Tay, C. Y. (2020). Interpenetrating network of alginate-human adipose extracellular matrix hydrogel for islet cells encapsulation. Macromolecular Rapid Communications, 41(21), 2000275-.
Project: DMP-1604
Journal: Macromolecular Rapid Communications
Abstract: Transplantation of microencapsulated islet cells holds great potential for the treatment of type 1 diabetes mellitus. However, its clinical translation is hampered by the peri-transplantation loss of islet viability and functionality in the microcapsules. In this work, a novel islet cells biomimetic microencapsulant material that is based on the interpenetrating networks of alginate and extracellular matrix (ECM) hydrogel composite (AEC) is presented. The ECM component is derived from human lipoaspirate. In situ encapsulation of pancreatic β islet cells (MIN6 β-cells) can be achieved via ionotropic gelation of the alginate matrix and thermal-induced gelation of the pepsin-solubilized ECM pre-gel. Due to the enhanced cell-matrix interaction, islets encapsulated within the AEC microcapsules (≈640 µm) display sevenfold increase in cell growth over 1 week of culture and characteristic glucose-stimulated insulin response in vitro. The results show that the AEC microcapsule is a potent platform to bioaugment the performance of islet cells.
ISSN: 1022-1336
DOI: 10.1002/marc.202000275
Schools: School of Materials Science and Engineering 
School of Biological Sciences 
Lee Kong Chian School of Medicine (LKCMedicine) 
Research Centres: Nanyang Environment and Water Research Institute 
Rights: © 2020 Wiley-VCH GmbH. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles
MSE Journal Articles
NEWRI Journal Articles
SBS Journal Articles

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