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dc.contributor.authorSelvan, Subramanian Tamilen_US
dc.contributor.authorRavichandar, Roopaen_US
dc.contributor.authorGhosh, Krishna Kantaen_US
dc.contributor.authorMohan, A.en_US
dc.contributor.authorMahalakshmi, Pachaiyappanen_US
dc.contributor.authorGulyás, Balázsen_US
dc.contributor.authorPadmanabhan, Parasuramanen_US
dc.identifier.citationSelvan, S. T., Ravichandar, R., Ghosh, K. K., Mohan, A., Mahalakshmi, P., Gulyás, B. & Padmanabhan, P. (2021). Coordination chemistry of ligands: insights into the design of amyloid beta/tau-PET imaging probes and nanoparticles-based therapies for Alzheimer's disease. Coordination Chemistry Reviews, 430, 213659-.
dc.description.abstractThe diagnosis and therapy of neurodegenerative diseases are highly indispensable. In particular, the definitive clinical diagnosis and therapy of Alzheimer's disease (AD) remains a challenge. Despite the use of amyloid beta (Aβ) positron emission tomography (PET) gold standard [11C]-PiB, other approved benzothiazole ([18F]-flutemetamol) and stilbene derivative ([18F]-florbetaben and [18F]-florbetapir) based probes have been extensively studied and advocated as potential early Aβ PET radioligands for AD. Recent years have witnessed a burgeoning research activity in the development of radiotracers for tau neurofibrillary tangles (NFTs) binding using PET imaging, while monitoring the progression of disease. Notably, several tau PET ligands (e.g. [18F]-THK5351, [18F]-MK-6240, and [18F]-AV-1451, [18F]-RO-6958948, [18F]-JNJ-64326067, [18F]-PI-2620) showed high affinity and selective binding to tau pathology. Although early detection and progression of AD have been studied extensively using PET imaging, therapeutic approaches to the disease are scarce. Recently, nanoparticles (NPs) based therapeutic approaches have emerged. Coordination of ligands to the surface of organic NPs (e.g., flavonoids: green tea polyphenol- EGCG, curcumin), and inorganic NPs (e.g. Au, ZnO, CeO2) have been explored to decrease/inhibit the amyloid aggregation and tau hyperphosphorylation. This review focuses on (i) the importance of coordination chemistry of ligands in the design of PET imaging probes with specific binding affinities to Aβ and tau NFTs in AD, and (ii) the role of surface ligands and their coordination to NPs and functional molecules for the rational design of novel anti-AD reagents for therapeutic interventions.en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.relation.ispartofCoordination Chemistry Reviewsen_US
dc.rights© 2020 Elsevier B.V. All rights reserved.en_US
dc.titleCoordination chemistry of ligands: insights into the design of amyloid beta/tau-PET imaging probes and nanoparticles-based therapies for Alzheimer's diseaseen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.subject.keywordsAlzheimer's Diseaseen_US
dc.subject.keywordsCoordination Chemistryen_US
dc.description.acknowledgementS.T.S., B.G., P.P. thank the support from Lee Kong Chian School of Medicine, Imaging Probe Development Platform, and Cognitive Neuro Imaging Centre (CONIC) at Nanyang Technological University (NTU) Singapore.en_US
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