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Title: Molecular probes for autofluorescence-free optical imaging
Authors: Jiang, Yuyan
Pu, Kanyi
Keywords: Engineering::Bioengineering
Engineering::Chemical engineering
Issue Date: 2021
Source: Jiang, Y. & Pu, K. (2021). Molecular probes for autofluorescence-free optical imaging. Chemical Reviews, 121(21), 13086-13131.
Project: 2019-T1-002-045
SERC A18A8b0059
Journal: Chemical Reviews
Abstract: Optical imaging is an indispensable tool in clinical diagnostics and fundamental biomedical research. Autofluorescence-free optical imaging, which eliminates real-time optical excitation to minimize background noise, enables clear visualization of biological architecture and physiopathological events deep within living subjects. Molecular probes especially developed for autofluorescence-free optical imaging have been proven to remarkably improve the imaging sensitivity, penetration depth, target specificity, and multiplexing capability. In this Review, we focus on the advancements of autofluorescence-free molecular probes through the lens of particular molecular or photophysical mechanisms that produce long-lasting luminescence after the cessation of light excitation. The versatile design strategies of these molecular probes are discussed along with a broad range of biological applications. Finally, challenges and perspectives are discussed to further advance the next-generation autofluorescence-free molecular probes for in vivo imaging and in vitro biosensors.
ISSN: 0009-2665
DOI: 10.1021/acs.chemrev.1c00506
Schools: School of Chemical and Biomedical Engineering 
School of Physical and Mathematical Sciences 
Rights: © 2021 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
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