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Title: Rosetting responses of plasmodium-infected erythrocytes to antimalarials
Authors: Lee, Wenn-Chyau
Russell, Bruce
Lau, Yee-Ling
Nosten, Francois
Rénia, Laurent
Keywords: Science::Biological sciences
Issue Date: 2022
Source: Lee, W., Russell, B., Lau, Y., Nosten, F. & Rénia, L. (2022). Rosetting responses of plasmodium-infected erythrocytes to antimalarials. American Journal of Tropical Medicine and Hygiene, 106(6), 1670-1674.
Project: OF-YIRG NMRC/OFYIRG/0070/2018
JCO-DP BMSI/15-800006-SIGN
Journal: American Journal of Tropical Medicine and Hygiene
Abstract: In malaria, rosetting is a phenomenon involving the cytoadherence of uninfected erythrocytes to infected erythrocytes (IRBC) harboring the late erythrocytic stage of Plasmodium spp. Recently, artesunate-stimulated rosetting has been demonstrated to confer a survival advantage to P. falciparum late-stage IRBC. This study investigated the rosetting response of P. falciparum and P. vivax clinical isolates to ex vivo antimalarial treatments. Brief exposure of IRBC to chloroquine, mefloquine, amodiaquine, quinine, and lumefantrine increased the rosetting rates of P. falciparum and P. vivax. Furthermore, the ex vivo combination of artesunate with mefloquine and piperaquine also resulted in increased the rosetting rates. Drug-mediated rosette-stimulation has important implications for the therapeutic failure of rapidly cleared drugs such as artesunate. However, further work is needed to establish the ramifications of increased rosetting rates by drugs with longer half-lifves, such as chloroquine, mefloquine, and piperaquine.
ISSN: 0002-9637
DOI: 10.4269/ajtmh.21-1229
Schools: School of Biological Sciences 
Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: Agency for Science, Technology and Research
Rights: © 2022 by The American Society of Tropical Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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