Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/161295
Title: Predictors of influenza PCR positivity in acute exacerbations of chronic obstructive pulmonary disease
Authors: Chen, Calvin You Jia
Yew, Min Sen
Abisheganaden, John Arputhan
Xu, Huiying
Keywords: Science::Medicine
Issue Date: 2022
Source: Chen, C. Y. J., Yew, M. S., Abisheganaden, J. A. & Xu, H. (2022). Predictors of influenza PCR positivity in acute exacerbations of chronic obstructive pulmonary disease. International Journal of Chronic Obstructive Pulmonary Disease, 17, 25-32. https://dx.doi.org/10.2147/COPD.S338757
Journal: International Journal of Chronic Obstructive Pulmonary Disease
Abstract: Purpose: Influenza infection is an important cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Clinical features predicting influenza PCR positivity are unknown. We aim to identify predictors of influenza PCR positivity in AECOPD. Patients and Methods: A retrospective study of AECOPD cases admitted between 1st January 2016 to 30 June 2017 with combined nasal/throat swabs sent for influenza PCR (Xpert Xpress Flu/RSV) within 24 hours of admission was performed. Clinical parameters and investigations within 24 hours of admission were retrieved from electronic medical records. Results: Influenza PCR were sent for 925 AECOPD cases (mean age 75 years, 87.9% male). There were 90 PCR positive cases (68 Influenza A, 22 Influenza B). Influenza PCR positive cases had higher temperatures, higher heart rates, lower white cell and lower eosinophil counts. Age, gender, COPD severity, comorbidities and smoking status were similar in both groups. There were no differences in blood pressure, oxygen status, neutrophil or lymphocyte counts, C reactive protein, procalcitonin or chest X-ray consolidation between groups. Higher temperature, higher heart rate, white cell count in the lowest quartile (Q1 < 8.1 x109 /L) and non-eosinophilic exacerbations predicted influenza PCR positivity on univariate logistic regression and these factors remained significant after multivariate adjustment (temperature adjusted odds ratio [adj OR] 1.324 [1.009–1.737], p = 0.043; heart rate adj OR 1.017 [1.004–1.030], p = 0.011; white cell count Q1 adj OR 3.330 [1.690–6.562], p = 0.001; eosinophilic exacerbations adj OR 0.390 [0.202–0.756], p = 0.005). Conclusion: Higher temperature, higher heart rate, low white cell count (especially when < 8.1 x109 /L) and non-eosinophilic exacerbations are independent predictors of influenza PCR positivity in AECOPD cases.
URI: https://hdl.handle.net/10356/161295
ISSN: 1178-2005
DOI: 10.2147/COPD.S338757
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2022 Chen et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

Files in This Item:
File Description SizeFormat 
COPD-338757-predictors-of-influenza-pcr-positivity-in-acute-exacerbation.pdf457.67 kBAdobe PDFThumbnail
View/Open

SCOPUSTM   
Citations 50

2
Updated on Jun 19, 2024

Web of ScienceTM
Citations 50

1
Updated on Oct 27, 2023

Page view(s)

87
Updated on Jun 20, 2024

Download(s) 50

45
Updated on Jun 20, 2024

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.