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dc.contributor.authorRen, Shi-Chaoen_US
dc.contributor.authorYang, Xingen_US
dc.contributor.authorMondal, Bivasen_US
dc.contributor.authorMou, Chenglien_US
dc.contributor.authorTian, Weiyien_US
dc.contributor.authorJin, Zhichaoen_US
dc.contributor.authorChi, Robin Yongguien_US
dc.identifier.citationRen, S., Yang, X., Mondal, B., Mou, C., Tian, W., Jin, Z. & Chi, R. Y. (2022). Carbene and photocatalyst-catalyzed decarboxylative radical coupling of carboxylic acids and acyl imidazoles to form ketones. Nature Communications, 13(1), 2846-.
dc.description.abstractThe carbene and photocatalyst co-catalyzed radical coupling of acyl electrophile and a radical precursor is emerging as attractive method for ketone synthesis. However, previous reports mainly limited to prefunctionalized radical precursors and two-component coupling. Herein, an N-heterocyclic carbene and photocatalyst catalyzed decarboxylative radical coupling of carboxylic acids and acyl imidazoles is disclosed, in which the carboxylic acids are directly used as radical precursors. The acyl imidazoles could also be generated in situ by reaction of a carboxylic acid with CDI thus furnishing a formally decarboxylative coupling of two carboxylic acids. In addition, the reaction is successfully extended to three-component coupling by using alkene as a third coupling partner via a radical relay process. The mild conditions, operational simplicity, and use of carboxylic acids as the reacting partners make our method a powerful strategy for construction of complex ketones from readily available starting materials, and late-stage modification of natural products and medicines.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.description.sponsorshipNanyang Technological Universityen_US
dc.description.sponsorshipNational Research Foundation (NRF)en_US
dc.relationMOE2019-T2-2- 117en_US
dc.relation.ispartofNature Communicationsen_US
dc.rights© 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
dc.titleCarbene and photocatalyst-catalyzed decarboxylative radical coupling of carboxylic acids and acyl imidazoles to form ketonesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.description.versionPublished versionen_US
dc.description.acknowledgementWe acknowledge financial supports from Singapore National Research Foundation under its NRF Investigatorship (NRF-NRFI2016-06, Y.R.C.) and Competitive Research Program (NRF-CRP22-2019-0002, Y.R.C.); the Ministry of Education, Singapore, un-der its MOE AcRF Tier 1 Award (RG7/20, Y.R.C.), MOE AcRF Tier 2 Award (MOE2019-T2-2- 117, Y.R.C.), MOE AcRF Tier 3 Award (MOE2018-T3-1-003, Y.R.C.); Chair Professorship Grant, Nanyang Technological University; the National Natural Science Foundation of China (21772029, Y.R.C.; 21801051, Z.J.; 21961006, Z.J.; 22071036, Y.R.C.; 22061007, Y.R.C.; 81360589, W.T.;), Frontiers Science Center for Asymmetric Synthesis and Medicinal Molecules, Department of Education, Guizhou Province [Qianjiaohe KY number (2020)004, Y.R.C.]; The 10 Talent Plan (Shicengci) of Guizhou Province ([2016] 5649, Y.R.C.); the Science and Technology Department of Guizhou Province ([2019] 1020, Y.R.C.); the Program of Introducing Talents of Discipline to Universities of China (111 Program, D20023, Y.R.C. & Z.J.) at Guizhou University; the Guizhou Province First-Class Disciplines Project [(Yiliu Xueke Jianshe Xiangmu)-GNYL(2017)008, W.T.], Research Center for precise catalytic construction and pharmacological activity of natural active molecules; Project of Qianfagai Gaoji ([2021]380, W.T.); Guizhou University of Traditional Chinese Medicine (China); and Guizhou University.en_US
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