Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/161351
Title: Prevalence of measles antibodies among migrant workers in Singapore: a serological study to identify susceptible population subgroups
Authors: Ang, Li Wei
Gao, Qi
Cui, Lin
Farwin, Aysha
Toh, Matthias Paul Han Sim
Boudville, Irving Charles
Chen, Mark I-Cheng
Chow, Angela
Lin, Raymond Tzer-Pin
Lee, Vernon Jian Ming
Leo, Yee Sin
Keywords: Science::Medicine
Issue Date: 2022
Source: Ang, L. W., Gao, Q., Cui, L., Farwin, A., Toh, M. P. H. S., Boudville, I. C., Chen, M. I., Chow, A., Lin, R. T., Lee, V. J. M. & Leo, Y. S. (2022). Prevalence of measles antibodies among migrant workers in Singapore: a serological study to identify susceptible population subgroups. BMC Infectious Diseases, 22(1), 88-. https://dx.doi.org/10.1186/s12879-022-07066-2
Project: MOHCS15MAR001
Journal: BMC Infectious Diseases 
Abstract: Background: In 2019, two clusters of measles cases were reported in migrant worker dormitories in Singapore. We conducted a seroprevalence study to measure the level of susceptibility to measles among migrant workers in Singapore. Methods: Our study involved residual sera of migrant workers from seven Asian countries (Bangladesh, China, India, Indonesia, Malaysia, Myanmar and the Philippines) who had participated in a survey between 2016 and 2019. Immunoglobulin G (IgG) antibody levels were first measured using a commercial enzyme-linked immunosorbent assay (ELISA) test kit. Those with equivocal or negative IgG results were further evaluated using plaque reduction neutralization test (PRNT). Results: A total of 2234 migrant workers aged 20–49 years were included in the study. The overall prevalence of measles IgG antibodies among migrant workers from the seven Asian countries was 90.5% (95% confidence interval 89.2–91.6%). The country-specific seroprevalence ranged from 80.3 to 94.0%. The seroprevalence was significantly higher among migrant workers born in 1965–1989 than those born in 1990–1999 (95.3% vs. 86.6%, p < 0.0005), whereas there was no significant difference by gender (90.8% in men vs. 89.9% in women, p = 0.508). 195 out of 213 samples with equivocal or negative ELISA results were tested positive using PRNT. Conclusion: The IgG seroprevalence in migrant workers was below the herd immunity threshold of 95% for measles. Sporadic outbreaks may occur in susceptible individuals due to high transmissibility of measles virus. Seroprevalence surveys can help identify susceptible subgroups for vaccination.
URI: https://hdl.handle.net/10356/161351
ISSN: 1471-2334
DOI: 10.1186/s12879-022-07066-2
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Organisations: National Centre for Infectious Diseases
Saw Swee Hock School of Public Health, National University of Singapore
Tan Tock Seng Hospital
Yong Loo Lin School of Medicine, National University of Singapore
Rights: © The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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