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Title: Biology of resident tissue macrophages
Authors: Lee, Christopher Zhe Wei
Ginhoux, Florent
Keywords: Science::Biological sciences
Issue Date: 2022
Source: Lee, C. Z. W. & Ginhoux, F. (2022). Biology of resident tissue macrophages. Development, 149(8).
Project: NRF2016NRF-NRFI001-02
Journal: Development
Abstract: Although best known for their phagocytic and immunological functions, macrophages have increasingly been recognised as key players in the development, homeostasis and regeneration of their host tissues. Early during development, macrophages infiltrate and colonise all tissues within the body, developing symbiotically with their host tissues and acquiring unique functional adaptations based on the tissue microenvironment. These embryonic resident tissue macrophages (RTMs) are ontogenically distinct from the later adult bone marrow-derived monocytes, and in some tissues are self-maintained independently of general circulation at a steady state. In this article, we briefly discuss the ontogeny, maintenance and unique tissue adaptions of RTMs focusing on microglia, Kupffer cells, Langerhans cells, intestinal macrophages, cardiac macrophages and tumour-associated macrophages, and highlight their role in development, homeostasis and dysfunction.
ISSN: 0950-1991
DOI: 10.1242/dev.200270
Schools: School of Biological Sciences 
Organisations: Singapore Immunology Network
Yong Loo Lin School of Medicine, National University of Singapore
Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre
Rights: © 2022 The authors. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SBS Journal Articles

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