Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/161378
Title: EndoPil: a magnetically actuated swallowable capsule for weight management: development and trials
Authors: Phan, Phuoc Thien
Tiong, Anthony Meng Huat
Miyasaka, Muneaki
Cao, Lin
Kaan, Hung Leng
Ho, Khek Yu
Phee, Soo Jay
Keywords: Engineering::Mechanical engineering
Issue Date: 2021
Source: Phan, P. T., Tiong, A. M. H., Miyasaka, M., Cao, L., Kaan, H. L., Ho, K. Y. & Phee, S. J. (2021). EndoPil: a magnetically actuated swallowable capsule for weight management: development and trials. Annals of Biomedical Engineering, 49(5), 1391-1401. https://dx.doi.org/10.1007/s10439-020-02692-w
Project: R-172-000-004-720
M4081419
Journal: Annals of Biomedical Engineering
Abstract: Intragastric balloons (IGBs), by occupying the stomach space and prolonging satiety, is a promising method to treat obesity and consequently improves its associated comorbidities, e.g. coronary heart disease, diabetes, and cancer. However, existing IGBs are often tethered with tubes for gas or liquid delivery or require endoscopic assistance for device delivery or removal, which are usually uncomfortable, costly, and may cause complications. This paper presents a novel tetherless, magnetically actuated capsule (EndoPil) which can deploy an IGB inside the stomach after being swallowed and being activated by an external magnet. The external magnet attracts a small magnet inside the EndoPil to open a valve, triggering the chemical reaction of citric acid and potassium bicarbonate to produce carbon dioxide gas, which inflates a biocompatible balloon (around 120 mL). A prototype, 13 mm in diameter and 35 mm in length, was developed. Simulations and bench-top tests were conducted to test the force capability of the magnetic actuation mechanism, the required force to activate the valve, and the repeatability of balloon inflation. Experiments on animal and human were successfully conducted to demonstrate the safety and feasibility of inflating a balloon inside the stomach by an external magnet.
URI: https://hdl.handle.net/10356/161378
ISSN: 0090-6964
DOI: 10.1007/s10439-020-02692-w
Schools: School of Mechanical and Aerospace Engineering 
Rights: © 2020 Biomedical Engineering Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MAE Journal Articles

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