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dc.contributor.authorSenese, Vincenzo Paoloen_US
dc.contributor.authorShinohara, Kazuyukien_US
dc.contributor.authorVenuti, Paolaen_US
dc.contributor.authorBornstein, Marc H.en_US
dc.contributor.authorRosanio, Vittorioen_US
dc.contributor.authorNasti, Carlaen_US
dc.contributor.authorNeoh, Michelle Jin-Yeeen_US
dc.contributor.authorMaresca, Marziaen_US
dc.contributor.authorEsposito, Gianlucaen_US
dc.identifier.citationSenese, V. P., Shinohara, K., Venuti, P., Bornstein, M. H., Rosanio, V., Nasti, C., Neoh, M. J., Maresca, M. & Esposito, G. (2022). The interaction effect of parental rejection and oxytocin receptor gene polymorphism on depression: a cross-cultural study in non-clinical samples. International Journal of Environmental Research and Public Health, 19(9), 5566-.
dc.description.abstractParental rejection has been consistently empirically implicated in a wide array of developmental, behavioural and psychological problems worldwide. However, the interaction effect between parental rejection in childhood and the oxytocin receptor genotype on psychological adjustment has yet to be investigated. The present study aimed to investigate gene-environment interaction effects between parental rejection (maternal and paternal) and oxytocin receptor (OXTR) gene polymorphisms (rs53576 and rs2254298) on depressive symptoms in adults in different cultural contexts. Adults from Italy and Japan (N = 133, age = 18-27 years, females = 68) were preliminarily genotyped and then completed the Parental Acceptance-Rejection Questionnaire for mothers and fathers and the Beck Depression Inventory. Hierarchical multiple regression analysis showed that paternal rejection was related to self-reported depression and that the effect of parental rejection was moderated by OXTR gene polymorphisms and nationality. Among Italians, OXTR rs2254298 A-carriers showed resilience to negative early parental care, whereas among Japanese, OXTR rs53576 non-A-carriers showed resistance to negative early paternal care. These findings align with expected relations between perceived acceptance-rejection and an individual's psychological adjustment, as proposed by interpersonal acceptance-rejection theory, and indicate the need for future studies adopting a multicultural and multilevel approach to better understand how the effects of parental rejection extend into adulthood.en_US
dc.relation.ispartofInternational Journal of Environmental Research and Public Healthen_US
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/).en_US
dc.subjectSocial sciences::Psychologyen_US
dc.titleThe interaction effect of parental rejection and oxytocin receptor gene polymorphism on depression: a cross-cultural study in non-clinical samplesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Social Sciencesen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsGene–Environment Interactionsen_US
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